Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial

Contemporary Clinical Dentistry
N PriyankaA R Pradeep

Abstract

The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Seventy subjects with probing depth (PD) ≥5 mm were selected. Thirty-five subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index, gingival index, clinical attachment level (CAL), and PD at baseline; 1 month, 3 months, and 6 months interval. Furthermore, microbial analysis using polymerase chain reaction was done to estimate the number of sites harboring periodontopathogens. Sixty four subjects were evaluated up to 6 months. At 6 months, the Group 2 resulted in greater mean reduction (4.10 mm) in PD as compared to Group 1 (1.49 mm), and also a greater mean CAL gain (4.20 mm) in Group 2 as compared to Group 1 (1.13 mm). These subjects also showed a significant reduction in the number of sites harboring periodontopathogens. The use of 3% SZ gel, when used as an adjunct to nonsurgical periodontal therapy in subjects with periodontitis, achieved better results than initial periodontal treatment alone.

Citations

Jan 16, 2020·Brazilian Oral Research·Vivianne Carvalho da Cunha TrajanoMaria Esperanza Cortés
Jan 16, 2020·Journal of Applied Oral Science : Revista FOB·Mauricio BaezaJorge Gamonal
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alicia AguilarGuoqiang Hua
Oct 6, 2021·JDR Clinical and Translational Research·J C GunsolleyE Ioannidou

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