Clinical and molecular complexity of breast cancer metastases

Seminars in Cancer Biology
Siker KimbungIngrid Hedenfalk

Abstract

Clinical oncology is advancing toward a more personalized treatment orientation, making the need to understand the biology of metastasis increasingly acute. Dissecting the complex molecular, genetic and clinical phenotypes underlying the processes involved in the development of metastatic disease, which remains the principal cause of cancer-related deaths, could lead to the identification of more effective prognostication and targeted approaches to prevent and treat metastases. The past decade has witnessed significant progress in the field of cancer metastasis research. Clinical and technological milestones have been reached which have tremendously enriched our understanding of the complex pathways undertaken by primary tumors to progress into lethal metastases and how some of these processes might be amenable to therapy. The aim of this review article is to highlight the recent advances toward unraveling the clinical and molecular complexity of breast cancer metastases. We focus on genes mediating breast cancer metastases and organ-specific tropism, and discuss gene signatures for prediction of metastatic disease. The challenges of translating this information into clinically applicable tools for improving the prognostication...Continue Reading

References

Apr 4, 1973·Nature: New Biology·I J Fidler
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
May 25, 2002·Seminars in Cancer Biology·Isaiah J Fidler
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Oleg Schmidt-KittlerChristoph A Klein
Jul 5, 2003·Cancer Cell·Yibin KangJoan Massagué
Dec 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Britta WeigeltLaura J van't Veer
Apr 20, 2004·Cancer Cell·Darren M Brown, Erkki Ruoslahti
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Sep 10, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J BursteinP Klein
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Mar 7, 2006·Cancer·Kenneth R HessJames L Abbruzzese
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Oct 20, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A ImkampeT Bates
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
Apr 19, 2007·Nature Reviews. Genetics·Don X Nguyen, Joan Massagué
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca DentSteven A Narod
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gaorav P GuptaJoan Massagué
Dec 13, 2007·Journal of the National Cancer Institute·Raimund JakeszUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
Jan 3, 2008·Cancer Cell·Yves HüsemannChristoph A Klein
Mar 12, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleftherios P MamounasNorman Wolmark
May 3, 2008·Cancer Research·Marcel SmidJohn W M Martens
May 6, 2008·The Breast : Official Journal of the European Society of Mastology·R Stuart-HarrisP Pharoah
Dec 26, 2008·The New England Journal of Medicine·Anne C Chiang, Joan Massagué
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
Mar 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SimmonsM J Clemons
Mar 25, 2009·Nature Reviews. Cancer·Don X NguyenJoan Massagué
Mar 25, 2009·Nature Reviews. Cancer·Christoph A Klein
Jun 19, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jun 26, 2009·The New England Journal of Medicine·Peter C FongJohann S de Bono
Jul 4, 2009·Cancer Cell·Xiang H-F ZhangJoan Massagué
Jul 15, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C LiedtkeA M Gonzalez-Angulo
Nov 7, 2009·Journal of the National Cancer Institute·Sacha J HowellAnne C Armstrong
Nov 26, 2009·Biochimica Et Biophysica Acta·Andriy Marusyk, Kornelia Polyak
Dec 22, 2009·Nature Medicine·Yvonne KienastFrank Winkler

❮ Previous
Next ❯

Citations

Oct 13, 2015·Seminars in Cancer Biology·Ira Skvortsova
Apr 12, 2016·Cancer Chemotherapy and Pharmacology·Ali Aboel DahabNorman W Smith
Jul 16, 2016·Stem Cells International·Wanyin ChenMaria Zeniou
Jan 6, 2017·Journal of Cancer Prevention·Azad KumarNilesh Kumar Sharma
Jan 20, 2017·Virchows Archiv : an International Journal of Pathology·István Artúr MolnárAnna-Mária Tőkés
Mar 10, 2017·Scientific Reports·Anne Bruun KrøigårdTorben A Kruse
Jun 8, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P RhanaA L P Rodrigues
Oct 11, 2017·Environmental Science and Pollution Research International·Yuanfang HeKusheng Wu
Aug 6, 2018·Breast Cancer Research and Treatment·Darko ZdravkovicMarija Zdravkovic
Apr 25, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Menghuan LiKaiyong Cai
Aug 21, 2019·Clinical and Experimental Pharmacology & Physiology·Priyank A ShenoyMaree T Smith
Feb 2, 2017·Oncotarget·Meijian LiaoYaou Zhang
Jan 3, 2018·International Journal of Molecular Sciences·Thaiz F BorinAli S Arbab
Dec 18, 2019·Current Medical Science·Shu-Ting JiangFei Su
Feb 10, 2018·Expert Review of Molecular Diagnostics·Suruchi MittalIngunn Holen
May 22, 2020·Frontiers in Oncology·Xiuming LiuLingyun Zhang
Mar 18, 2016·International Journal of Oncology·Iliet PayanSéverine Van Slambrouck
Apr 11, 2017·Molecular Medicine Reports·Shuhang GaoXuesong Yang
Dec 28, 2018·Cancers·Marta Tellez-GabrielDominique Heymann
Feb 23, 2021·Therapeutic Advances in Medical Oncology·Marion BerthoJean-Sébastien Frénel
Mar 2, 2021·World Journal of Gastrointestinal Oncology·Jie TangMing Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Avrum SpiraCharles A Powell
Cytogenetic and Genome Research
Virginia Urquidi, S Goodison
Clinical & Experimental Metastasis
Keltouma DriouchRosette Lidereau
© 2021 Meta ULC. All rights reserved