Clinical and morphological factors predictive of occult involvement of the nipple-areola complex in mastectomy specimens

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Paulo R PirozziSebastião Piato

Abstract

To evaluate characteristics predictive of nipple-areola complex (NAC) involvement by the breast tumor. Cases of infiltrative ductal carcinoma (stages I, IIA and IIB) treated by mastectomy in which the distance between the tumor and the NAC was >or=2 cm were included. NAC involvement was evaluated using serial histological sections. The distance between the tumor and the NAC was measured on mammograms. Other parameters taken into consideration were: tumor size, histological and nuclear grades, vascular invasion, and the presence of an in situ component. For comparisons between categorical variables, the chi-square test or Fisher's exact test were used. Student's t-test was used for numerical variables with normal distribution and the Mann-Whitney U-test was applied when distribution was not normal. Fifty patients were included. NAC was affected in 12 and unaffected in 38. There was no statistically significant difference in mean age between the unaffected and affected groups (58.9+/-13.5 years versus 55.8+/-12.5 years, p=0.477); however, 13.2% and 58.3% (p=0.046) in the NAC-unaffected and NAC-affected groups, respectively, were <50 years of age. Distance <or=3 cm between the tumor and the NAC on mammograms was found in 60.5% of ...Continue Reading

References

Mar 1, 1990·Annals of the Royal College of Surgeons of England·C C BishopA G Nash
Jan 1, 1987·The British Journal of Surgery·M W Kissin, A E Kark
Apr 18, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J J VyasJ S Vaidya
Jan 31, 2002·Plastic and Reconstructive Surgery·J Arthur Jensen
Nov 27, 2004·The Breast : Official Journal of the European Society of Mastology·N FersisD Wallwiener
Jul 11, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F CarusoG Carillio
Aug 22, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K P Benediktsson, L Perbeck
Jan 22, 2008·American Journal of Surgery·Margaret J LoewenTimothy L Fitzgerald
Mar 26, 2008·Ultrasound Quarterly·Beverly E HashimotoMarie Lee
Oct 29, 2008·Advances in Surgery·Claire S CooneyTheodore N Tsangaris
Apr 22, 2009·AJR. American Journal of Roentgenology·Amy M SchellPetra J Lewis
Jul 28, 2009·Journal of the American College of Surgeons·Richard J BleicherMonica Morrow
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rajini KatipamulaMatthew P Goetz

❮ Previous
Next ❯

Citations

May 1, 2013·Plastic and Reconstructive Surgery·Peter MallonFabien Reyal
Sep 12, 2012·Annals of Surgical Oncology·Shawn T SteenArmando E Giuliano
Jul 12, 2014·Annales de chirurgie plastique et esthétique·J-G FéronF Reyal
Jan 31, 2012·The Breast Journal·Vijayashree Murthy, Ronald S Chamberlain
Nov 22, 2012·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Vijayashree Murthy, Ronald S Chamberlain
May 25, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J R Morales PiatoE C Baracat
Apr 22, 2015·Breast Cancer Research and Treatment·Hanwen ZhangQifeng Yang
Jan 13, 2015·Virchows Archiv : an International Journal of Pathology·Dipti M KaramchandaniJulie Mack
Aug 13, 2014·World Journal of Clinical Oncology·Alexandre Mendonça MunhozRolf Gemperli
Mar 20, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Lingxiao PanWenbo Zheng
Jan 26, 2017·Plastic and Reconstructive Surgery·Roy De VitaMarcello Pozzi
Sep 13, 2017·World Journal of Surgery·Yolanda Ho-Yan ChanPolly Suk-Yee Cheung
May 19, 2017·Molecular and Clinical Oncology·Barbara DullJulie A Margenthaler
Sep 21, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Hirohito SekiKen Shimizu

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