Clinical and MRI outcome of cervical spine lesions in children with juvenile idiopathic arthritis treated with anti-TNFα drugs early in disease course

Pediatric Rheumatology Online Journal
Damjana KljučevšekTadej Avčin

Abstract

The purpose of the study was to evaluate the clinical and magnetic resonance imaging (MRI) outcome of cervical spine arthritis in children with juvenile idiopathic arthritis (JIA), who received anti-TNFα early in the course of cervical spine arthritis. Medical charts and imaging of JIA patients with cervical spine involvement were reviewed in this retrospective study. Data, including age at disease onset, JIA type, disease activity, treatment and clinical outcome were collected. Initial and followup MRI examinations of cervical spine were performed according to the hospital protocol to evaluate the presence of inflammation and potential chronic/late changes. Fifteen JIA patients with MRI proved cervical spine inflammation (11 girls, 4 boys, median age 6.3y) were included in the study: 9 had polyarthritis, 3 extended oligoarthritis, 2 persistent oligoarthritis and 1 juvenile psoriatic arthritis. All children were initially treated with high-dose steroids and methotrexate. In addition, 11 patients were treated with anti-TNFα drug within 3 months, and 3 patients within 7 months of cervical spine involvement confirmed by MRI. Mean observation time was 2.9y, mean duration of anti-TNFα treatment was 2.2y. Last MRI showed no active in...Continue Reading

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Citations

Jul 5, 2018·Expert Review of Clinical Immunology·Clara MalattiaAlberto Martini
Apr 17, 2020·Clinical Rheumatology·Ana Tripalo BatošAlenka Gagro
Dec 18, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Scott C SeamanArnold H Menezes
Dec 8, 2020·Best Practice & Research. Clinical Rheumatology·Clara MalattiaAndrea S Doria
Jul 31, 2021·Annals of Emergency Medicine·Umang JainEva Delgado

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