Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism

Brain : a Journal of Neurology
Takamitsu WatanabeHidenori Yamasue

Abstract

Autism spectrum disorder is a prevalent neurodevelopmental disorder with no established pharmacological treatment for its core symptoms. Although previous literature has shown that single-dose administration of oxytocin temporally mitigates autistic social behaviours in experimental settings, it remains in dispute whether such potentially beneficial responses in laboratories can result in clinically positive effects in daily life situations, which are measurable only in long-term observations of individuals with the developmental disorder undergoing continual oxytocin administration. Here, to address this issue, we performed an exploratory, randomized, double-blind, placebo-controlled, crossover trial including 20 high-functional adult males with autism spectrum disorder. Data obtained from 18 participants who completed the trial showed that 6-week intranasal administration of oxytocin significantly reduced autism core symptoms specific to social reciprocity, which was clinically evaluated by Autism Diagnostic Observation Scale (P = 0.034, PFDR < 0.05, Cohen's d = 0.78). Critically, the improvement of this clinical score was accompanied by oxytocin-induced enhancement of task-independent resting-state functional connectivity be...Continue Reading

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Citations

Feb 2, 2016·Neuroscience and Biobehavioral Reviews·Arthur Lefevre, Angela Sirigu
Mar 26, 2016·Brain : a Journal of Neurology·Dimitri M Kullmann
Aug 23, 2016·Frontiers in Neuroendocrinology·Sarah J Baracz, Jennifer L Cornish
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Mar 29, 2019·Molecular Autism·Florina UzefovskySimon Baron-Cohen
Mar 28, 2017·BMC Neuroscience·Haruhiro HigashidaOlga Lopatina

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