PMID: 15334844Sep 1, 2004Paper

Clinical and pathologic comparison of acute leptospirosis in dogs caused by two strains of Leptospira kirschneri serovar grippotyphosa

American Journal of Veterinary Research
Justin J GreenleeClaire B Andreasen

Abstract

To develop a method for inducing acute leptospirosis in dogs. 31 nine-week-old female Beagles. Beagles were randomly assigned to 2 inoculation groups or a control group. Dogs were inoculated on 3 successive days by conjunctival instillation of 5 x 10(7) cells of Leptospira kirschneri serovar grippotyphosa strain 82 (12 dogs) or strain RM 52 (14 dogs). Control dogs (n = 5) were similarly inoculated with sterile leptospiral culture media. Clinical signs, clinicopathologic variables, anti-leptospiral antibody titers, and evidence of leptospires in tissues and body fluids were evaluated. Dogs were euthanatized and necropsied on days 7, 14, 22, or 28 after inoculation or as required because of severe illness. Clinical signs in infected dogs included conjunctivitis, lethargy, diarrhea, dehydration, vomiting, and icterus. Consistent clinicopathologic alterations included azotemia, hyperphosphatemia, increased anion gap, hyperbilirubinemia, and an increase in alkaline phosphatase activity. Leptospires were cultured from the kidneys (11/12), urine (6/9), aqueous humor (9/12), blood (12/12), and liver (12/12) of dogs inoculated with strain 82. Only 3 of 14 dogs became infected after inoculation with strain RM 52. Histopathologic lesions ...Continue Reading

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Citations

Jul 24, 2008·Journal of Veterinary Internal Medicine·E H ApplemanS Al-Ghazlat
Dec 16, 2010·Journal of Veterinary Internal Medicine·J E SykesR E Goldstein
Nov 23, 2010·BMC Infectious Diseases·Suneth B AgampodiVasanthi Thevanesam
Nov 9, 2005·American Journal of Veterinary Research·Justin J GreenleeClaire B Andreasen
Jun 5, 2007·Journal of the American Veterinary Medical Association·Jennifer E StokesCarole A Bolin
Oct 19, 2013·Journal of the American Veterinary Medical Association·Lindsay E Tangeman, Meryl P Littman
Aug 1, 2009·Journal of Veterinary Emergency and Critical Care·Ariane SchweighauserThierry Francey
Apr 26, 2006·Veterinary Ophthalmology·Wendy M TownsendSheryl G Krohne
Mar 11, 2015·The Journal of Small Animal Practice·S SchullerJ Sykes
Dec 25, 2012·Journal of Medical Microbiology·Nobuo KoizumiMakoto Ohnishi
Oct 3, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Daniel R Rissi, Cathy A Brown
Nov 8, 2011·Journal of the American Animal Hospital Association·Alexander Gallagher
Sep 7, 2004·Journal of the American Animal Hospital Association·Louis-Philippe de Lorimier, Joanne B Messick
Jan 15, 2021·Journal of Immunoassay & Immunochemistry·Olusola Lawrence AjayiTemitope Morenikeji Oladipo
Oct 7, 2008·The Veterinary Record·I van de MaeleS Daminet

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