Clinical and pathologic predictors of clinical outcome of malignant pleural mesothelioma

Tumori
Rossana BerardiStefano Cascinu

Abstract

Although worldwide use of asbestos has decreased, the incidence of malignant pleural mesothelioma (MPM) is expected to increase over the next few decades. A number of scoring systems has been proposed to assess clinicopathologic features and to predict the prognosis. We assessed the relationship between patients' features and disease evolution in order to choose the best treatment able to prolong overall survival (OS) and progression-free survival (PFS). We retrospectively analyzed patients with locally advanced or metastatic MPM, treated at the Department of Medical Oncology, Università Politecnica Marche, Italy, from January 2003 to September 2013. Data on age, sex, smoking history, asbestos exposure, performance status, tumor stage, histology, type of treatment, and routine laboratory tests including complete blood count panel, date of death, or censored status were collected. The OS and PFS were estimated using Kaplan-Meier method and Cox analysis was performed to analyze the prognostic relevance of clinical parameters. We enrolled a total of 62 patients. Univariate analysis showed that histologic type, performance status, response to first-line therapy, pretreatment hemoglobin levels, and plasmatic Ca125 were significant p...Continue Reading

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Citations

Dec 28, 2016·The Clinical Respiratory Journal·Panagiotis PaliogiannisAlessandro Fois
Dec 11, 2020·BMC Cancer·Dearbhaile Catherine CollinsAnna Minchom
Jun 3, 2021·Journal of Clinical Medicine·Amedeo IaffaldanoLudovic Fournel

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