Clinical and Pathological Aspects of Silent Pituitary Adenomas

The Journal of Clinical Endocrinology and Metabolism
Juliana DrummondMárta Korbonits

Abstract

Silent pituitary adenomas are anterior pituitary tumors with hormone synthesis but without signs or symptoms of hormone hypersecretion. They have been increasingly recognized and represent challenging diagnostic issues. A comprehensive literature search was performed using MEDLINE and EMBASE databases from January 2000 to March 2018 with the following key words: (i) pituitary adenoma/tumor and nonfunctioning; or (ii) pituitary adenoma/tumor and silent. All titles and abstracts of the retrieved articles were reviewed, and recent advances in the field of silent pituitary adenomas were summarized. The clinical and biochemical picture of pituitary adenomas reflects a continuum between functional and silent adenomas. Although some adenomas are truly silent, others will show some evidence of biochemical hypersecretion or could have subtle clinical signs and, therefore, can be referred to as clinically silent or "whispering" adenomas. Silent tumors seem to be more aggressive than their secreting counterparts, with a greater recurrence rate. Transcription factors for pituitary cell lineages have been introduced into the 2017 World Health Organization guidelines: steroidogenic factor 1 staining for gonadotroph lineage; PIT1 (pituitary-s...Continue Reading

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Citations

Jul 11, 2019·Lipids in Health and Disease·Alaleh Bayat BarooniMasoumeh Tavakoli-Yaraki
Mar 5, 2020·The New England Journal of Medicine·Shlomo Melmed
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Methods Mentioned

BETA
transcription factor profiling
electron microscopy

Clinical Trials Mentioned

NCT03271918
NCT02288962
NCT01283542
NCT01620138
NCT02749227

Software Mentioned

PASSILCORT

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