Clinical and pathological aspects of thymic epithelial tumors.

General Thoracic and Cardiovascular Surgery
Meinoshin OkumuraYoshiki Sawa

Abstract

A histological classification of thymic epithelial tumors was presented by the World Health Organization (WHO) in 1999 and again in 2004 following slight modifications, in which thymic epithelial tumors were categorized as thymomas and thymic carcinomas. Whereas thymoma is defined as an organotypic (thymus-like) tumor, thymic carcinoma is a malignant epithelial neoplasm with a morphology similar to that of malignant neoplasms arising from other organs. Herein, the recent progress in research of thymic epithelial tumors is reviewed with reference to the WHO histological classification system, with the focus on thymomas. Thymomas are classified into five types--A, AB, B1, B2, B3--according to the shape and atypia of their epithelial cells as well as the abundance of lymphocytes. The invasiveness, prognosis, and genetic imbalance of thymomas have been shown to be related to this classification system. Myasthenia gravis is frequently associated with types B1 and B2. The WHO histological classification of thymomas is not only useful for treatment but reflects their biological characteristics, including genetic alterations. Advances are expected in future studies of thymomas from the standpoint of their clinical, pathological, and bi...Continue Reading

References

Mar 1, 1976·The Journal of Pathology·J M Papadimitriou
Jan 1, 1991·The Annals of Thoracic Surgery·G MaggiE Ruffini
Jun 1, 1991·The Annals of Thoracic Surgery·E W WilkinsD J Mathisen
Jan 1, 1990·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·G MaggiM Molinatti
Oct 1, 1995·The Annals of Thoracic Surgery·D BlumbergV Rusch
Jul 15, 1994·Cancer·L Quintanilla-MartinezN L Harris
Aug 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J F RegnardP Levasseur
Feb 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·M OkumuraH Matsuda
Jun 26, 1999·Histopathology·S YonedaH K Müller-Hermelink
Jul 29, 1999·British Journal of Cancer·J C NicholsonD W Ellison
Aug 26, 1999·The British Journal of Ophthalmology·J M MAcKENZIE
Sep 9, 1999·American Journal of Clinical Pathology·S Suster, C A Moran
Oct 16, 1999·Annals of Surgery·K B WilkinsG B Bulkley
Jul 6, 2000·The American Journal of Pathology·A ZettlA Marx
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Hidefumi SasakiYoshitaka Fujii
Sep 20, 2002·AJR. American Journal of Roentgenology·Noriyuki TomiyamaHironobu Nakamura
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Roland PenzelRalf J Rieker
Oct 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Kazuo NakagawaRyosuke Tsuchiya
Apr 6, 2004·The Annals of Thoracic Surgery·Kazuya KondoYasumasa Monden
May 30, 2006·The Annals of Thoracic Surgery·Frank C Detterbeck

❮ Previous
Next ❯

Citations

Dec 12, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Charat ThongprayoonJettanong Klaewsongkram
Apr 7, 2009·Der Nervenarzt·B JordanS Zierz
Oct 11, 2008·Medical Oncology·Xiao-Feng LiYun-Bin Ye
Jan 25, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pier Luigi FilossoFrancesco Guerrera
Dec 18, 2010·Revue des maladies respiratoires·V Thomas De Montpréville
Oct 15, 2014·Journal of Medical Case Reports·Said R BeydounRichard Alan Rison
Sep 1, 2010·Nuclear Medicine and Molecular Imaging·Ji Young KimJin-Sook Ryu
May 4, 2013·Revue neurologique·M BouchikhA Benosman
Apr 24, 2012·Pediatric Neurology·Dimitrije M NikolicPetar I Ivanovski
Apr 17, 2009·American Journal of Clinical Pathology·Maoxin WuDavid E Burstein
Jan 18, 2011·Journal of the Neurological Sciences·Andrea RigamontiElio Agostoni
Nov 30, 2010·Current Problems in Cancer·Jeffrey A Forquer
Nov 13, 2010·Thoracic Surgery Clinics·Mirella Marino, Mauro Piantelli
Nov 13, 2010·Thoracic Surgery Clinics·Masahiro Yanagawa, Noriyuki Tomiyama
Aug 25, 2015·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Keiji OhataYasuji Terada
Sep 17, 2011·Muscle & Nerve·Paola CavalcanteRenato Mantegazza
Oct 22, 2008·Biochemical and Biophysical Research Communications·Zhaodi GuAkira Horii
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Guo-Bing LiuSu-Jun Zhou
Mar 31, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Pier Luigi FilossoMarco Lucchi
May 12, 2011·Toxicologic Pathology·J A SchwartzW O Iverson
Jul 30, 2010·International Journal of Surgical Pathology·Zhi-yi ZhouJia-bei Liang
Mar 23, 2010·The American Journal of Surgical Pathology·Marc HartertChristian-Friedrich Vahl
Apr 13, 2010·Autoimmunity·A MarxP Ströbel
Jan 8, 2013·The Veterinary Record·A Rostaher PrélaudJ Hein
Apr 24, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Sureyya SarıhanDeniz Sıgırlı

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