Clinical and pathological characteristics of polymethylmethacrylate and hyaluronic acid in the rat tongue

International Journal of Oral and Maxillofacial Surgery
Sabrina P MoureMaria Antonia Z de Figueiredo

Abstract

Adverse effects on the oral mucosa after the use of dermal fillers have been increasingly reported due to their increased use for facial aesthetics. The objective of this study was to evaluate the clinical and histologic effects of two types of product, 10% polymethylmethacrylate and 20mg/ml hyaluronic acid, locally and at long distance, examining initial and late reactions. Each substance was randomly and separately injected in rats' tongues (polymethylmethacrylate, n = 16; hyaluronic acid, n = 18). They were compared with the control group (n = 16) at 3 observation times (7, 60 and 90 days) for clinical analysis, intensity of local inflammatory response (haematoxylin and eosin staining), amount of newly formed blood vessels and macrophages (immunohistochemical assays), density of collagen fibres (picrosirius staining) and systemic migration of the product to the liver and kidney (haematoxylin and eosin staining). The results showed inflammation triggered by the injection of the material, suggesting that both substances cause responses in local tissue, although there was biocompatibility with hyaluronic acid. This research highlights the importance of experimental studies on this subject, since adverse reactions have been obse...Continue Reading

References

Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Dec 3, 2003·Aesthetic Plastic Surgery·Gottfried LemperleUlrich Charrier
Jan 15, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T LombardiR Küffer
Apr 3, 2004·Plastic and Reconstructive Surgery·Gottfried LemperleRichard L Gallo
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·M Maurer, E von Stebut
Mar 5, 2005·Seminars in Cutaneous Medicine and Surgery·Klaus Laeschke
Mar 5, 2005·Seminars in Cutaneous Medicine and Surgery·Ute S Zimmermann, Thierry J Clerici
Mar 11, 2005·Aesthetic Plastic Surgery·Lise ChristensenEstrid Hogdall
Jul 25, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Paul C EdwardsRobert Iovino
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Jan 19, 2008·Journal of Cutaneous Pathology·Ophelia Entsir DadzieJag Bhawan
Jan 14, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Bruno C JhamHelen Rivera
Feb 27, 2009·International Journal of Oral and Maxillofacial Surgery·M C da Costa MiguelL B de Souza
Mar 4, 2011·Aesthetic Plastic Surgery·Ozcan CakmakHasan Tanyeri
Jul 16, 2011·The Open Dentistry Journal·Sabrina P MoureManoel Sant Ana Filho
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ruchielli Loureiro BorghettiMaria Antonia Zancanaro de Figueiredo

❮ Previous
Next ❯

Citations

Oct 13, 2014·Journal of Endodontics·Fernanda Ullmann LópezFabiana Vieira Vier-Pelisser
Jan 25, 2014·Gerodontology·Karlon F VargasMaria Antonia Z de Figueiredo
Jul 23, 2013·International Journal of Oral and Maxillofacial Surgery·C C G MedeirosM A Z de Figueiredo
Mar 8, 2013·Gerodontology·Clarissa C G MedeirosMaria Antonia Z de Figueiredo
Jul 23, 2015·Brazilian Dental Journal·Fernanda Ullmann LópezFabiana Vieira Vier-Pelisser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Japanese Journal of Ophthalmology
Toshinobu Kubota, Hiroshi Hirose
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Ruchielli Loureiro BorghettiMaria Antonia Z de Figueiredo
The Journal of Oral Implantology
Sarosh F DastoorHom-Lay Wang
© 2021 Meta ULC. All rights reserved