Clinical and prognostic analysis of hepatitis B virus infection in diffuse large B-cell lymphoma.

BMC Cancer
Feng WangZhong-zhen Guan

Abstract

Hepatitis B virus (HBV) infection in diffuse large B-cell lymphoma (DLBCL) patients is a common complication in China. However, the clinical relevance of HBV infection with respect to DLBCL disease stages and patient survival remains unclear. The main objective of the current study was to analyze the clinical features and to evaluate the prognostic factors of HBV infection in DLBCL patients. In this retrospective study, DLBCL patients were divided into two groups as HBsAg-positive (n = 81) and HBsAg-negative (n = 181) patients. The HBsAg-positive patients were further divided into two subgroups based on their hepatic function during chemotherapy. Various statistical analyses were used to determine the significance of the relevant clinical parameters. Compared with the HBsAg-negative group, the HBsAg-positive DLBCL group displayed a younger median onset age (46 year vs 51), more advanced stage at grade III/IV (58% vs 42%, p = 0.016), and more frequent hepatic dysfunction before (21% vs 5.5%, p < 0.001) and during (49.4% vs 16.6%, p < 0.001) chemotherapy. Female DLBCL patients exhibited a higher frequency of HBsAg positivity (p = 0.006). However, in both groups the median overall survival (OS) duration (55.8 vs 66.8 months) and r...Continue Reading

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Citations

Nov 16, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yin-Hua WangWei Xu
Feb 12, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Huang RuofanLiang Xiaohua
Apr 29, 2009·Leukemia & Lymphoma·Ron RamPia Raanani
Jun 10, 2014·Expert Opinion on Biological Therapy·Mauro ViganòPietro Lampertico
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Sep 11, 2014·Gastroenterología y hepatología·María Luisa Gutiérrez GarcíaConrado Manuel Fernández Rodriguez
Jul 12, 2012·The Korean Journal of Hematology·Jooryung Huh
Apr 4, 2017·International Journal of Cancer. Journal International Du Cancer·Xiao-Li WeiRui-Hua Xu
May 10, 2017·Hematology·Cheng-Shyong ChangSheng-Lei Yan
Mar 3, 2021·Leukemia & Lymphoma·Xiaosheng Fang, Ken H Young
Oct 15, 2021·Blood Advances·Concepción Fernández-RodríguezAntonio Salar

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Methods Mentioned

BETA
Enzyme-linked immunosorbent assay
ICE
biopsy

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