Clinical and Prognostic Significance of Preoperative Plasma Fibrinogen Levels in Patients with Operable Breast Cancer

PloS One
Yu MeiRong Ma

Abstract

Elevated plasma fibrinogen levels are associated with tumor progression and poor outcomes in different cancer patients. The objective of this study was to investigate the clinical and prognostic value of preoperative plasma fibrinogen levels in patients with operable breast cancer. Two hundred and twenty-three patients diagnosed with breast cancer were retrospectively evaluated in this study. Plasma fibrinogen levels were examined before treatment and analyzed along with patient clinicopathological parameters, disease-free survival (DFS) and overall survival (OS). Both univariate and multivariate analyses were performed to identify the clinicopathological parameters associated with DFS and OS. Elevated preoperative plasma fibrinogen levels were directly associated with age of diagnose (≤47 vs. >47, p<0.001), menopause (yes vs. no, p<0.001), tumor size (T1&T2 vs. T3&T4, p = 0.033), tumor stage (I vs. II vs. III, p = 0.034) and lymph node involvement (N = 0 vs. 1≤N≤3 vs. N≥4, p<0.001), but not with histological grade, molecular type and other Immunohistochemical parameters (ER, PR, HER2 and Ki-67). In a univariate survival analysis, tumor stage, tumor size, lymph node involvement (p<0.001/p<0.001) and plasma fibrinogen (p<0.001/p...Continue Reading

References

Dec 4, 1992·Annals of the New York Academy of Sciences·H F DvorakD R Senger
Oct 1, 1990·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·D L Amrani
Mar 1, 1995·European Heart Journal·S E Humphries
Mar 23, 2002·The Lancet Oncology·Gregory Y H LipAndrew D Blann
Nov 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil GoldenbergSusan Solymoss
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·M W Mosesson
May 16, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Mark JonesAlastair N Graham
Nov 4, 2006·Blood·Glenys A TennentMark B Pepys
Mar 25, 2009·American Journal of Obstetrics and Gynecology·Stephan PolterauerLukas Hefler
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole M KudererCharles W Francis
Sep 30, 2010·Journal of Thrombosis and Haemostasis : JTH·R KanzI Pabinger
Mar 1, 2012·Haematologica·Cihan AyIngrid Pabinger
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Aug 12, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J NiA Yu

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Citations

Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu MeiRong Ma
Sep 11, 2018·Hematology·Amira Mohamed Foad ShehataSuzy F Gohar
Feb 6, 2017·BioMed Research International·Yuejun TianZhiping Wang
Apr 11, 2018·World Journal of Gastroenterology : WJG·Wei-Yu XuHai-Tao Zhao

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