Clinical and Radiographic Features of Giant Cell Arteritis With Intracranial Involvement

ACR Open Rheumatology
Catalina Sanchez-AlvarezK J Warrington

Abstract

Giant cell arteritis (GCA) is a large-vessel vasculitis that primarily affects the aorta and its branches. Extracranial branches of the carotid artery are frequently affected; however, intracranial involvement in GCA is rare. A retrospective medical record review was performed to identify all patients with intracranial GCA (IC-GCA) from January 1996 through May 2018. Nine patients with IC-GCA were included (78% male; mean age, 72.1 years [SD: 7.9]). All patients met ACR criteria for GCA. The median time from onset of GCA to intracranial involvement was 0.6 months (interquartile range: 0.1-5.1). All patients had neurologic symptoms, 89% had an ischemic cerebrovascular event. Transient or permanent vision loss was frequent (56% of patients). IC-GCA was diagnosed by cranial imaging in all nine patients. Intracranial vasculitis most commonly affected the internal carotid artery (100%), followed by the vertebral artery (67%), posterior cerebral artery (67%), middle cerebral artery (44%), anterior cerebral artery (33%), and posterior inferior cerebral artery (11%). Intracranial vessel stenosis was present in 89%, occlusion in 33%, wall thickening in 33%, and dilation in 11%. All patients received glucocorticoids. Additional therapeut...Continue Reading

References

Aug 1, 1996·Controlled Clinical Trials·M Schemper, T L Smith
Mar 2, 2011·Arthritis and Rheumatism·Cynthia S CrowsonSherine E Gabriel
Aug 30, 2014·AJNR. American Journal of Neuroradiology·S SiemonsenT A Bley
Jan 17, 2016·The Journal of Rheumatology·Roaa S AlsolaimaniLillian J Barra
Aug 23, 2016·Seminars in Arthritis and Rheumatism·Patompong UngprasertKenneth J Warrington
Jul 27, 2017·The New England Journal of Medicine·John H StoneNeil Collinson
Jul 10, 2018·Rheumatology·Matthew J KosterKenneth J Warrington

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Citations

Apr 6, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Odysseas KargiotisGeorgios Tsivgoulis

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Methods Mentioned

BETA
PCA
biopsy
ESR

Software Mentioned

RedCap
R Foundation for
SAS
R

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