Clinical and radiographic findings in children with spontaneous lymphatic malformation regression

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Jonathan A PerkinsEunice Y Chen

Abstract

Evaluate clinical and radiographic characteristics of spontaneously regressing lymphatic malformations ("lesions"). Retrospective review of 104 consecutive patients with cervicofacial lesions, with 1-year follow-up. patient's age; lesion stage, location, radiographic characteristics; treatment. Data analysis using descriptive and Fischer exact tests. Spontaneously regressing lesions were identified in 13 of 104 (12.5%) patients. Five of 13 had in utero lesions, which persisted at birth; presenting age in the remaining eight patients was 2 to 138 months. Lesions regressed within 2 to 7 months. Lesion stage: I (7 of 13), II (2 of 13), III (4 of 13). Lesion location: left neck (9 of 13), right neck (4 of 13), posterior neck (10 of 13). All 13 resolving lesions were macrocystic with fewer than five septations in 11 of 13. Comparison of a resolving lesion cohort with a nonresolving lesion cohort demonstrated that disappearing lesions are more likely to have fewer than five septae and to be macrocystic (P < 0.05). Treatment was none in seven of 13, antibiotics in four of 13, and redundant skin excision in two of 13. Spontaneous lesion regression can occur, and these lesions have distinct features. Lesions with these characteristics c...Continue Reading

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Citations

May 25, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jonathan A PerkinsMark A Egbert
Jun 19, 2009·Lymphatic Research and Biology·Eunice Y ChenJonathan A Perkins
Jun 22, 2011·Lymphatic Research and Biology·Andrew L KirshJonathan A Perkins
Jul 21, 2011·The Journal of Craniofacial Surgery·Claire SangerLouis C Argenta
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Sep 17, 2010·Journal of Vascular Surgery·Yaowu YangDelin Lei
Nov 21, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Beck LongstreetManjiri Dighe
Jun 8, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Karthik BalakrishnanJonathan A Perkins
Jul 13, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mary Theresa AdamsJonathan A Perkins
Aug 16, 2017·Experimental and Therapeutic Medicine·Jing MaTie-Song Zhang
Oct 26, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Scott C Manning, Jonathan Perkins
Apr 21, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Ashoke KhanwalkarJohn Maddalozzo
Dec 7, 2018·Current Treatment Options in Pediatrics·Reema PadiaJonathan Perkins
May 13, 2021·PloS One·Nemanja RankovicRadoje Simic
Sep 14, 2021·Head & Neck·Daniela P MeirellesMaria C F de Aguiar

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Methods Mentioned

BETA
surgical resection

Software Mentioned

STATA

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