Clinical and radiological outcomes of proactive Gamma Knife surgery for asymptomatic meningiomas compared with the natural course without intervention

Journal of Neurosurgery
Kyung Hwan KimJung-Il Lee

Abstract

OBJECTIVEThis study aimed to verify the effect of proactive Gamma Knife surgery (GKS) in the treatment of asymptomatic meningioma compared with the natural course without any therapeutic intervention.METHODSFrom January 2006 to May 2017, 354 patients newly diagnosed with asymptomatic meningioma were reviewed and categorized into GKS (n = 153) and observation (n = 201) groups. Clinical and radiological progression rates were examined, and changes in volume were analyzed.RESULTSClinical progression (i.e., clinician-judged progression), combining symptomatic progression (n = 43) and clinician-judged increase in size using images routinely acquired (n = 34), occurred in 4 patients (2.6%) and 73 patients (36.3%) in the GKS and observation groups, respectively (p < 0.001). The clinical progression-free survival (PFS) rates in the GKS and observation groups were 98.7% and 64.6%, respectively, at 5 years (p < 0.001), and 92.9% and 42.7%, respectively, at 10 years (p < 0.001). The radiological tumor control rate was 94.1% in the GKS group, and radiological progression was noted in 141 patients (70.1%) in the observation group. The radiological PFS rates in the GKS and observation groups were 94.4% and 38.5%, respectively, at 5 years (p ...Continue Reading

References

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Citations

Sep 29, 2019·Current Treatment Options in Neurology·Michele BailoPietro Mortini
Dec 14, 2019·Neuro-oncology Practice·Maziar BehbahaniBente Sandvei Skeie
May 12, 2020·Brain Tumor Research and Treatment·Sung Kwon KimUNKNOWN KSNO Guideline Working Group
Feb 6, 2020·Neurologia Medico-chirurgica·Satoshi Nakasu, Yoko Nakasu
Nov 20, 2020·Acta neurochirurgica·Stylianos PikisJason Sheehan
Dec 22, 2020·Computer Methods and Programs in Biomedicine·Annabelle CollinBenjamin Taton

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