PMID: 7259347Aug 1, 1981Paper

Clinical and secretory differences in pancreatic cancer and chronic pancreatitis

Annals of Surgery
R L GoodaleD S Fryd

Abstract

The differential diagnosis between chronic pancreatitis and pancreatic cancer can be very difficult. In 60 patients with either of these conditions, who had satisfactory ERCP study, clinical features were correctly matched with the final diagnosis by discriminant analysis in 44 (73%). The sensitivity of ERCP radiographic findings in pancreatic cancer was 80% and sensitivity of cytology was 54%. To see if exocrine function was specific for cancer, fresh pancreatic secretions were aspirated in 27 patients at the time of ERCP. By isoelectric focusing, a pattern of extreme zymogen depletion was observed in chronic alcoholic pancreatitis (Group 1), pancreatic cancer (Group 2), and chronic nonalcoholic pancreatitis (Group 3). The three groups were not distinguishable. By contrast, significant changes in albumin, IgG and IgA concentrations were seen in Group 2. The albumin level was over ten-fold greater than in Groups 1 and 3 (p less than 0.02 and less than 0.05). The IgG was seven-fold and two-fold greater (p less than 0.01 and greater than 0.2) and the IgA was 15-fold and six-fold greater (p less than 0.002 and less than 0.05) than in Groups 1 and 3, respectively. The two groups of pancreatitis had similar concentrations of albumin...Continue Reading

References

Jul 18, 1977·JAMA : the Journal of the American Medical Association·L R McCormackW B Strum
May 1, 1977·AJR. American Journal of Roentgenology·R A Wilkins, A Hatfield
Feb 1, 1979·Annals of Surgery·T T White, A H Slavotinek
Mar 1, 1979·Annals of Surgery·R L GoodaleK Gajl-Peczalska
Oct 6, 1977·The New England Journal of Medicine·E P DiMagnoV L Go
Feb 1, 1973·American Journal of Surgery·E F RosatoF E Rosato
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jan 1, 1969·American Journal of Surgery·K W Warren
Mar 15, 1981·Cancer·R L GoodaleJ Samuelson

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Citations

Sep 1, 1983·Digestive Diseases and Sciences·T T WhiteH Miyashita
Mar 1, 1985·Digestive Diseases and Sciences·T T WhiteH Miyashita
Apr 25, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·K HayakawaT Nagamine
Dec 11, 2008·Journal of Gastroenterology and Hepatology·Antonio M Morselli-Labate, Raffaele Pezzilli
Jan 1, 1985·Acta Pathologica Japonica·H SaitoH Nagura

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