Clinical and serologic factors associated with lupus pleuritis

The Journal of Rheumatology
Shikha MittooChristine A Peschken

Abstract

Pleuritis is a common manifestation and independent predictor of mortality in systemic lupus erythematosus (SLE). We examined the prevalence of pleuritis and factors associated with pleuritis in a multicenter Canadian SLE cohort. We studied consecutive adults satisfying the American College of Rheumatology (ACR) classification criteria for SLE who had a completed Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) score, at least 1 evaluable extractable nuclear antigen assay, and either a SLE Disease Activity Index (SLEDAI) or a SLE Activity Measure score. Pleuritis was defined as having pleuritis by satisfying the ACR criteria or the SLEDAI. Factors related to pleuritis were examined using univariate and multivariate logistic regression. In our cohort of 876 patients, 91% were women, 65% Caucasian, mean age (+/- SD) was 46.8 +/- 13.5 years, and disease duration at study entry was 12.1 +/- 9.9 years; the prevalence of pleuritis was 34% (n = 296). Notably, greater disease duration (p = 0.002), higher SDI score (p <or= 0.0001), age at SLE diagnosis (p = 0.009), and anti-Sm (p = 0.002) and anti-RNP (p = 0.002) seropositivity were significantly associated with pleuritis. In multivariate analysis with adjustmen...Continue Reading

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Citations

Jun 3, 2014·La Presse médicale·Pamela M K LutaloDavid P D'Cruz
Nov 10, 2017·Lupus Science & Medicine·Seungwon RyuMichelle A Petri
Nov 25, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Nattawan PalavutitotaiWanruchada Katchamart

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