Clinical and Serological Characterization of the α-Gal Syndrome-Importance of Atopy for Symptom Severity in a European Cohort.

The Journal of Allergy and Clinical Immunology. in Practice
M B Gea KiewietMarianne van Hage

Abstract

The galactose-α1,3-galactose (α-Gal) syndrome (AGS) is a novel form of food allergy. Patients experience delayed severe allergic reactions after mammalian meat consumption due to IgE antibodies directed against the carbohydrate α-Gal present in mammalian meat. The onset of the disease is associated with tick bites. To characterize a cohort of patients with AGS from Sweden on a clinical and serological level, and identify risk factors for disease severity. A total of 128 patients with symptoms after mammalian meat intake and IgE to α-Gal were included. Medical examination and diagnosis were made by an allergologist and questionnaires were filled in regarding onset of symptoms, tick exposure, and airborne allergies. Serum IgE reactivity against multiple food and airborne allergens, as well as protein extract from the tick Ixodes ricinus, was measured using ImmunoCAP. The majority of patients were middle aged, with equal gender distribution. Nearly all reported symptoms more than 2 hours after meat consumption. Urticaria (90%) and gastrointestinal symptoms (74%) were most common. Almost half of the patients suffered from anaphylaxis, and α-Gal IgE levels were significantly higher among these patients compared with those without an...Continue Reading

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Citations

Jul 7, 2020·Expert Review of Molecular Diagnostics·José de la FuenteIván Pacheco
Nov 10, 2020·Frontiers in Immunology·Miriam HilsTilo Biedermann
Nov 19, 2020·Allergy·Mensiena Berentje Geertje KiewietMarianne van Hage
May 15, 2021·The Biochemical Journal·Alejandro Cabezas-CruzJosé de la Fuente
Mar 4, 2021·Allergy·Thomas A Platts-MillsAnna Pomés

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