Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus.

Clinics
Mariana PostalSimone Appenzeller

Abstract

To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity, laboratory findings and treatment features. We screened consecutive childhood-onset systemic lupus erythematosus patients in a longitudinal cohort at the pediatric rheumatology unit of the State University of Campinas between 2009 and 2010. All patients demonstrated disease onset before the age of 16. Disease status was assessed according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Interferon alpha levels were measured using an enzyme-linked immunoabsorbent assay. We included 57 childhood-onset systemic lupus erythematosus patients (mean age 17.33 ± 4.50), 64 first-degree relatives (mean age 39.95 ± 5.66), and 57 healthy (mean age 19.30 ± 4.97) controls. Serum interferon alpha levels were significantly increased in childhood-onset systemic lupus erythematosus patients compared to their first-degree relatives and healthy controls. Interferon alpha levels were ...Continue Reading

Citations

Aug 14, 2015·Autoimmunity Reviews·Cécile PicardAlexandre Belot
Jun 27, 2014·International Journal of Rheumatic Diseases·Amita Aggarwal, Puja Srivastava
Feb 25, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Graciela S Alarcón
Oct 1, 2012·International Journal of Clinical Rheumatology·Ashley J Wilhelm, Amy S Major
Mar 1, 2013·Expert Review of Clinical Immunology·Jeremy Di Domizio, Wei Cao
Aug 23, 2017·Pharmaceutical Medicine·Nailú Angélica SinicatoTimothy B Niewold
Dec 23, 2017·Frontiers in Immunology·Emily A HemannRam Savan
Dec 4, 2020·International Journal of Rheumatic Diseases·Manuela Nunes DrehmerSara Emelie Löfgren
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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