Clinical and Serological Predictors of Suicide in Schizophrenia and Major Mood Disorders

The Journal of Nervous and Mental Disease
Faith B DickersonRobert H Yolken

Abstract

Persons with serious mental illness are at high risk for suicide, but this outcome is difficult to predict. Serological markers may help to identify suicide risk. We prospectively assessed 733 persons with a schizophrenia spectrum disorder, 483 with bipolar disorder, and 76 with major depressive disorder for an average of 8.15 years. The initial evaluation consisted of clinical and demographic data as well as a blood samples from which immunoglobulin G antibodies to herpes viruses and Toxoplasma gondii were measured. Suicide was determined using data from the National Death Index. Cox proportional hazard regression models examined the role of baseline variables on suicide outcomes. Suicide was associated with male sex, divorced/separated status, Caucasian race, and elevated levels of antibodies to Cytomegalovirus (CMV). Increasing levels of CMV antibodies were associated with increasing hazard ratios for suicide. The identification of serological variables associated with suicide might provide more personalized methods for suicide prevention.

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Citations

Dec 18, 2019·Medicina·Marco PaoliniMaurizio Pompili
May 26, 2020·BMC Public Health·Eissa SoleymaniYounes Mohammadi
Mar 29, 2020·European Archives of Psychiatry and Clinical Neuroscience·Maija LindgrenJaana Suvisaari
Jan 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Haixia ZhengJonathan Savitz
Jun 29, 2021·Frontiers in Psychiatry·Teodor T PostolacheLisa A Brenner

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