Clinical and serological profile of asymptomatic and non-severe symptomatic COVID-19 cases: Lessons from a longitudinal study in primary care in Latin America.

BJGP Open
Klaus PuschelJoaquin Montero

Abstract

Chile has one of the highest incidences of COVID-19 infection in the world. Primary care can play a key role in early detection and containment of the disease. There is a lack of information on the clinical profile of patients with suspected COVID-19 in primary care, and controversy on the effectiveness of rapid serologic tests in the diagnosis and surveillance of the disease. To assess the effectiveness of rapid serologic testing in detection and surveillance of COVID-19 cases in primary care. A longitudinal study was undertaken, which was based on a non-random sample of 522 participants, including 304 symptomatic patients and 218 high-risk asymptomatic individuals. They were receiving care at four primary health clinics in an underserved area in Santiago, Chile. The participants were systematically assessed and tested for COVID-19 with reverse transcriptase-polymerase chain reaction (RT-PCR) and serology at baseline, and were followed clinically and serologically for 3 weeks. The prevalence rate of RT-PCR confirmed COVID-19 cases were 3.5 times higher in symptomatic patients (27.5%; 95% confidence interval [CI] = 22.1 to 32.8) compared with asymptomatic participants (7.9%; 95% CI = 4.3 to 11.6). Similarly, the immune response...Continue Reading

References

Sep 5, 2017·Bulletin of the World Health Organization·Cara S KosackPaul R Klatser
Mar 4, 2020·JAMA : the Journal of the American Medical Association·C Jason WangRobert H Brook
Mar 23, 2020·The Lancet Infectious Diseases·Yang LiuWei Zhang
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juanjuan ZhaoZheng Zhang
Apr 25, 2020·The Lancet Infectious Diseases·Sarah Ee Fang YongVernon J M Lee
Apr 25, 2020·The Lancet Infectious Diseases·Amy K Winter, Sonia T Hegde
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 13, 2020·JAMA Internal Medicine·Wenhua LiangUNKNOWN China Medical Treatment Expert Group for COVID-19
May 21, 2020·The Journal of General Virology·Paul Kellam, Wendy Barclay
May 23, 2020·Diagnostics·Panagiota I KontouPantelis G Bagos
Jun 20, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
Jun 24, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Michael R Kidd
Jun 26, 2020·BMJ : British Medical Journal·Chris Baraniuk
Jul 3, 2020·BMJ : British Medical Journal·Mayara Lisboa BastosFaiz Ahmad Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Elizabeth Temkin, Healthcare Worker COVID-19 Surveillance Working Group
MedRxiv : the Preprint Server for Health Sciences
Shane P ComerPatricia B Maguire
© 2021 Meta ULC. All rights reserved