Clinical and virological characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Kensei GotohHiroshi Kimura

Abstract

Chronic active Epstein-Barr virus (EBV) infection is characterized by recurrent infectious mononucleosis-like symptoms, and infected patients have high viral loads in their peripheral blood. Standard therapy for the disease has not yet been established. Recently, hematopoietic stem cell transplantation (HSCT) has been introduced and has the potential to become a standard treatment, although guidelines for HSCT to treat chronic active EBV infection have not yet been proposed. Fifteen patients were retrospectively analyzed, both clinically and virologically, to investigate the factors associated with prognosis of chronic active EBV infection treated with HSCT. After HSCT, 7 patients died after survival periods that ranged from 1 to 16 months (mean duration of survival after HSCT, 5 months). Three patients were considered to have died of transplantation-related complications. The duration between infection onset and diagnosis was significantly longer in patients who died than in those who survived. Five of the 7 patients who died experienced > or =3 life-threatening complications. The plasma concentrations of interferon-gamma, interleukin-10, thrombomodulin, and soluble E-selectin did not differ significantly between the groups of...Continue Reading

References

Jul 1, 1989·The Journal of Clinical Investigation·K Kawa-HaK Hirai
Mar 1, 1988·The Journal of Infectious Diseases·S E Straus
Oct 1, 1994·The Journal of General Virology·W E MillerN Raab-Traub
Jan 1, 1993·Annals of Internal Medicine·S E StrausJ Meier
Jul 1, 1997·The Journal of Infectious Diseases·H KaneganeG Tosato
Dec 17, 1998·Journal of Clinical Microbiology·H KimuraT Morishima
May 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H KaneganeG Tosato
Aug 17, 2000·The New England Journal of Medicine·J I Cohen
Feb 25, 2003·The Journal of Infectious Diseases·Hiroshi KimuraUNKNOWN Japanese Association for Research on Epstein-Barr Virus and Related Diseases
Dec 25, 2003·Journal of Virology·Rachel H EdwardsNancy Raab-Traub
Nov 16, 2004·Journal of Medical Virology·Hongxin FanMargaret L Gulley
Jan 19, 2005·The Journal of Infectious Diseases·Hiroshi KimuraTsuneo Morishima

❮ Previous
Next ❯

Citations

Apr 15, 2011·International Journal of Hematology·Ayako AraiOsamu Miura
Jun 12, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J I CohenE S Jaffe
May 21, 2013·The Journal of Infectious Diseases·Yoshihiko KawanoYoshinori Ito
Jan 15, 2011·Clinical Microbiology Reviews·Oludare A OdumadeHenry H Balfour
Jun 4, 2014·Dermatologic Clinics·Rattanavalai Nitiyarom, Chanisada Wongpraparut
Apr 17, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Barbara Gärtner, Jutta K Preiksaitis
Dec 30, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshinori ItoHiroshi Kimura
Mar 11, 2016·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Shunsuke YuiKoiti Inokuchi
Nov 27, 2008·Pediatric Transplantation·Jeffrey I Cohen
Oct 14, 2011·Pediatric Blood & Cancer·Donald R ShafferStephen Gottschalk
Dec 23, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kohei KanoNaoyuki Hasebe
Jan 30, 2018·Frontiers in Immunology·Hiroshi Kimura, Jeffrey I Cohen
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen Gottschalk
May 22, 2008·Reviews in Medical Virology·Hiroshi KimuraYukihiro Nishiyama
Aug 25, 2012·Uirusu·Hiroshi Kimura
Aug 2, 2012·The Tohoku Journal of Experimental Medicine·Yuichi SakamotoKohmei Kubo
Feb 9, 2013·Expert Review of Clinical Immunology·Stephanie Ruf, Hans-Joachim Wagner
Oct 10, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rongbei LiuZhinong Jiang
Jan 6, 2021·Internal and Emergency Medicine·Roberto CastoldiGiulia Carla Marchetti
Nov 5, 2020·Cancers·Shigeyoshi Fujiwara, Hiroyuki Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.