Clinical and virological characteristics of chronic hepatitis B with concurrent hepatitis B E antigen and antibody detection

Journal of Viral Hepatitis
J WangJ Hou

Abstract

The concurrent detection of hepatitis B e antigen (HBeAg) and its corresponding antibody (anti-HBe) in patients with chronic hepatitis B virus (HBV) infection is well established but the clinical features remain poorly understood. Demographic information, clinical and laboratory data were collected from 1624 consecutive inpatient records of patients with chronic hepatitis B. Viral genotype, basic core promoter and precore mutations were determined by direct sequencing. In vitro HBeAg and anti-HBe binding experiments were conducted with three pairs of HBeAg-positive and anti-HBe-positive serum samples, which were mixed at variable ratios and incubated at 37°C for 3-24h. Of the 1624 chronic patients, 169 (10.4%) had concurrent HBeAg and anti-HBe positivity, and this was associated with intermediate age and HBV-DNA load, higher alanine aminotransferase level and more pronounced liver damage compared with HBeAg-positive or anti-HBe-positive patients alone. HBeAg and anti-HBe titres (median and interquartile range, S/CO) in the concurrent positive group were 4.2 (1.8-9.6) and 0.54 (0.27-0.72), which were closer to their respective cut-off values than those of HBeAg-positive or anti-HBe-positive groups alone. For the cases successful...Continue Reading

References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Oct 1, 1993·Gastroenterology·T MaruyamaD R Milich
Jun 1, 1993·The Journal of Clinical Investigation·T MaruyamaD R Milich
Apr 1, 1996·The Journal of Clinical Investigation·B RehermannF V Chisari
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Sep 14, 2001·Journal of Viral Hepatitis·G V Papatheodoridis, S J Hadziyannis
Jan 20, 2006·International Journal of Medical Sciences·Chee Kent LimSo Har Ton
Mar 23, 2007·Journal of Clinical Microbiology·Zhanhui WangJinlin Hou
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ji-Ming ZhangMengji Lu
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wolfram H Gerlich
Jan 16, 2009·The New England Journal of Medicine·Juan Miguel BerguaHelena Bañas
Feb 17, 2009·Lancet·Yun-Fan Liaw, Chia-Ming Chu
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian J McMahon
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Haresh Mani, David E Kleiner

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