Abstract
In large stage III lung tumors, planning delivery of doses exceeding 60 Gy can be challenging and time consuming. Intensity modulated radiation therapy (IMRT) can improve target coverage but may increase volumes receiving low-dose irradiation. We clinically implemented a novel hybrid IMRT (h-IMRT) technique that allowed plans to be produced quickly, and compared these plans with 4 other techniques. h-IMRT was used to treat 14 consecutive patients with planning target volumes (PTVs) exceeding 500 cm(3) (average, 779 cm(3)) with concurrent chemo-radiation therapy to 66 Gy. h-IMRT plans consisted of 2 components: an anterior-posterior/posterior-anterior/posterior-anterior (AP-PA-PA) oblique, open-field technique delivering an average dose of 58 Gy, plus a 3-field IMRT component optimized to achieve a final homogeneous dose of 66 Gy. Total lung V(20) and contralateral lung V(5) were kept as low as possible but preferably less than 35% and less than 50%, respectively. All plans were retrospectively replanned using a 5- to 9-field 3-dimensional conformal technique, full RapidArc, 6-field full IMRT, and a hybrid RapidArc (h-RapidArc) technique similar to the h-IMRT. The h-IMRT, h-RapidArc, and full RapidArc plans could be generated in...Continue Reading
References
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M V GrahamC A Perez
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·M L DirkxB J Heijmen
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Ritsuko KomakiRoger W Byhardt
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·H Helen LiuRadhe Mohan
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Aaron M AllenElizabeth H Baldini
Sep 26, 2006·International Journal of Radiation Oncology, Biology, Physics·Shulian WangRitsuko Komaki
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Charles S MayoMadeleine Bogdanov
Oct 28, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jim RoseDavid D'Souza
Jun 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Zhongxing X LiaoJames D Cox
Jul 28, 2009·Lancet·Kathy S AlbainJames D Cox
Feb 24, 2010·Medical Physics·Laurence CourtTania Lingos
Mar 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Chang Hoon SongKwan Ho Cho
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Jul 3, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E C J PhernambucqS Senan
Jul 16, 2010·International Journal of Radiation Oncology, Biology, Physics·ChinLoon OngSuresh Senan
Nov 16, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Chin Loon OngSuresh Senan
Nov 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk De RuysscherSuresh Senan
Apr 12, 2011·International Journal of Radiation Oncology, Biology, Physics·Ivan S VogeliusSøren M Bentzen
Citations
Jan 18, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gwendolyn H M J GriffioenSuresh Senan
Aug 21, 2013·Acta Oncologica·Ellen J F van ReijSuresh Senan
Nov 11, 2014·Acta Oncologica·Gerrit J BlomSuresh Senan
Oct 8, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·John Agapito
Feb 24, 2016·Acta Oncologica·Daan HoffmansWilko F A R Verbakel
Mar 5, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sashendra SenthiSuresh Senan
Apr 3, 2016·Medical Physics·Jim P TolWilko F A R Verbakel
Mar 25, 2016·Scientific Reports·Jia-Yang LuBao-Tian Huang
Jun 23, 2015·Critical Reviews in Oncology/hematology·Benoite MéryNicolas Magné
Sep 16, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M AyadiF Mornex
Jul 3, 2015·The British Journal of Radiology·J-Y LuB-T Huang
Sep 26, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Max Dahele, Suresh Senan
Jan 30, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Terry G WiersmaSuresh Senan
Dec 17, 2014·The British Journal of Radiology·J-Y LuB-T Huang
Mar 15, 2015·PloS One·Jia-Yang LuLiang-Xi Xie
Jul 2, 2015·PloS One·Jia-Yang LuLiang-Xi Xie
Jun 24, 2015·Journal of Applied Clinical Medical Physics·Marloes JeulinkWilko F A R Verbakel
Sep 30, 2016·Technology in Cancer Research & Treatment·Scott R SilvaMehee Choi
Jun 29, 2017·Journal of Applied Clinical Medical Physics·Weijie LeiLiqin Hu
Jun 18, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Sitaraman BalajiSubramanianSumana Premkumar
Jun 27, 2013·Radiation Oncology·Petra S KroonMarion Essers
Mar 15, 2019·Asia-Pacific Journal of Clinical Oncology·Phillip ParenteEmily Stone
Oct 27, 2015·Scientific Reports·Jia-Yang LuWu-Zhe Zhang
May 8, 2019·Indian Journal of Cancer·Benoite MeryNicolas Magné
Oct 27, 2021·Journal of Applied Clinical Medical Physics·YanHua DuanZhiYong Xu