Clinical Application of Concentrated Growth Factor Fibrin Combined With Bone Repair Materials in Jaw Defects

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Dongdong FangJun Hou

Abstract

We investigated the promoting effect of concentrated growth factor (CGF) fibrin on the repair of jaw bone defects. We designed a clinical trial composed of patients with jaw defects. Forty patients were divided into the test and control groups. CGF fibrin combined with Bio-Oss bone powder (Giestlich Pharma, Wolhusen, Switzerland) was used in the test group. Bio-Oss bone powder alone was used in the control group. The concentration of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β in the red blood cell (RBC) layer and CGF gel was measured. At different time points before and after surgery, the serum bone alkaline phosphatase (BAP), osteocalcin, and bone mineral density levels were measured. Regular examinations and computed tomography scans were also performed in the follow-up period. The CGF fibrin available for clinical use was obtained by centrifugation. One day after preparation by centrifugation, the VEGF and TGF-β concentration in the CGF gel was 2.57-fold and 3.4-fold greater than the concentration in the RBC layer, respectively. The BAP and osteocalcin levels increased at 1 and 12 weeks postoperatively in both groups. Furthermore, the BAP and osteocalcin levels in the test group were sig...Continue Reading

Citations

Mar 18, 2021·International Journal of Oral Science·Bowen TanJinfeng Liao
Oct 26, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·T PourlakM Yousefi

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