PMID: 16535795Mar 16, 2006Paper

Clinical application of human tissue engineered skin with full thickness on donor site of split thickness skin graft in burn wounds

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Yaling LiuHou'an Xiao

Abstract

To observe the clinical effect of the human tissue engineered active skin (ActivSkin) with full thickness on the donor site of the split thickness skin graft. Nine patients with 18 wounds of the donor sites, and every patient had 2 wounds. The wounds of each patient were randomly assigned to the therapy group and the control group. Auto-control observation was performed. Nine donor sites of the split thickness skin graft were repaired with ActivSkin in the therapy group. Nine donor sites of the split thickness skin graft were repaired with the vash oil gauze in the control group. The wound pain, the time to complete closure, and the ratio of the complete healing in the ActivSkin therapy group was measured and compared with those in the control group. The donor sites of the split thickness skin graft were assessed at 180 days of the follow-up visit. The wound pain was obviously reduced after the harvesting of the skin grafts in the therapy group. The time to complete closure on the donor sites of the split thickness skin graft was significantly shorter in the ActivSkin therapy group than in the control group (9.67 +/- 2.92 d vs. 16. 56 +/- 2.96 d, P < 0.05). Both the ratios of the complete healing in the ActivSkin therapy group ...Continue Reading

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