Clinical application of mesenchymal stem cells in periodontal regeneration: A systematic review and meta-analysis

Journal of Periodontal Research
Solen NovelloSylvie Jeanne

Abstract

To evaluate the potential efficacy of mesenchymal stem cells (MSCs) in periodontal regeneration in humans on the following main outcomes: clinical attachment level (CAL), probing depth (PD), and gingival recession (GR). The clinical application of stem cells in periodontal regeneration has begun in recent years, but clinical practices are not yet standardized and no recommendations are available at this time. Electronic database searches and hand searches were conducted. All types of studies, case series, and case reports were qualitatively described. Double-blind randomized controlled trials (RCTs) evaluating MSCs in periodontal regeneration were included in a meta-analysis if they compared administration of MSCs vs application of stem cell-free therapy in the control group, in healthy patients with periodontal defects, with a minimum of three mo of follow-up. Fifteen reports were included in qualitative analysis, involving 123 patients and 158 periodontal defects. Only two small RCTs at high risk of bias, with a total of 59 patients and 70 periodontal defects, were included in the meta-analysis. A small but significant difference between test and control groups was found for CAL at three mo (-0.90 mm, 95% CI [-1.51; -0.29]), ...Continue Reading

References

Jul 1, 1982·Journal of Clinical Periodontology·J LindheE Westfelt
Jan 1, 1996·Connective Tissue Research·A S Narayanan, P M Bartold
Nov 2, 2004·Journal of Periodontology·Hiroyuki KawaguchiHidemi Kurihara
Apr 28, 2005·Journal of Periodontal Research·Tatsuya AkizukiIsao Ishikawa
Jul 12, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gregorio LainoGianpaolo Papaccio
Jul 12, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xuesong ChenArthur E Broadus
Nov 22, 2005·Lancet·Bruce L PihlstromNewell W Johnson
Apr 21, 2006·The Cochrane Database of Systematic Reviews·I G NeedlemanR J Tucker
May 12, 2006·Periodontology 2000·P Mark BartoldMalcolm L Snead
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
May 19, 2010·Journal of Periodontology·Karina Gonzales SilvérioFrancisco Humberto Nociti
Mar 12, 2011·Journal of Clinical Periodontology·Fabricia Ferreira SuaidEnilson Antônio Sallum
Apr 12, 2011·International Endodontic Journal·F J Rodríguez-LozanoJ M Moraleda
Apr 29, 2011·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Jayashree A Mudda, Monika Bajaj
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Apr 18, 2012·Periodontology 2000·Kim HynesP Mark Bartold
Jun 15, 2012·Biomaterials·Fa-Ming ChenQing Yu
Dec 12, 2012·Stem Cells·Yoichi YamadaToshihiko Wakabayashi
Apr 12, 2013·Periodontology 2000·Lisa J A Heitz-Mayfield, Niklaus P Lang
May 3, 2013·Journal of Periodontology·Gerard J LindenFrank A Scannapieco
May 17, 2013·Journal of Clinical Periodontology·Na YuJohn A Jansen
Jan 1, 2009·Language Learning and Development : the Official Journal of the Society for Language Development·Daniel J WeissAaron D Mitchel
Apr 20, 2014·Stem Cells Translational Medicine·Paul MonsarratPhilippe Kémoun
Oct 16, 2014·Journal of Periodontology·Mark A ReynoldsMarc L Nevins
Mar 31, 2015·World Journal of Stem Cells·Miki Taketomi SaitoFrancisco Humberto Nociti
Apr 11, 2015·Circulation Research·Vasileios Karantalis, Joshua M Hare
Jun 13, 2015·BioMed Research International·Miguel Padial-MolinaPablo Galindo-Moreno
Nov 3, 2015·Current Oral Health Reports·Mi DuPishan Yang
Nov 8, 2016·Stem Cells International·Athina Bakopoulou, Imad About
Apr 4, 2017·Journal of Cellular Physiology·Eiman Abdel MeguidAhmed H K El-Hashash
Apr 11, 2017·Journal of Periodontal Research·S A TassiC C Villar
Apr 19, 2017·Journal of Clinical Periodontology·Maurizio S TonettiJoan Otomo-Corgel
Dec 15, 2017·The International Journal of Periodontics & Restorative Dentistry·Mario AimettiFederica Romano

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Citations

Apr 14, 2020·Stem Cell Reviews and Reports·Ali GolchinAbdolreza Ardeshirylajimi
Feb 18, 2021·Tissue Engineering. Part B, Reviews·Jacob Ren Jie ChewMandeep Singh Duggal
Apr 27, 2021·Journal of Clinical Periodontology·Danae A ApatzidouAntonis Konstantinidis

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