Clinical application of pharmacogenetics

Trends in Molecular Medicine
B B SpearJ Huff

Abstract

Pharmacogenetics encompasses the involvement of genes in an individual's response to drugs. As such, the field covers a vast area including basic drug discovery research, the genetic basis of pharmacokinetics and pharmacodynamics, new drug development, patient genetic testing and clinical patient management. Ultimately, the goal of pharmacogenetics is to predict a patient's genetic response to a specific drug as a means of delivering the best possible medical treatment. By predicting the drug response of an individual, it will be possible to increase the success of therapies and reduce the incidence of adverse side effects.

References

Dec 1, 1995·Pharmacogenetics·S H Sindrup, K Brøsen
Feb 3, 1998·Nature Biotechnology·A Marshall, J Hodgson
Jul 24, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·C OrlandoM Pazzagli
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·E IsraelC N Yandava

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Citations

Mar 9, 2012·Analytical and Bioanalytical Chemistry·Katharina HartmannJürgen Popp
Dec 6, 2005·European Journal of Clinical Pharmacology·H S SüzenT Erke
Jun 29, 2010·European Journal of Clinical Pharmacology·Guillermo GervasiniJuan Antonio Carrillo
Mar 23, 2011·World Journal of Surgery·F Charles BrunicardiChangyi Chen
Apr 14, 2011·Human Genetics·Parvin Tajik, Patrick M Bossuyt
Apr 6, 2004·Trends in Pharmacological Sciences·Magnus Ingelman-Sundberg
Jun 18, 2002·Trends in Molecular Medicine·Julie A Johnson, William E Evans
Jan 10, 2012·Nature Medicine·Richard S BlumbergFrank O Nestle
Sep 14, 2001·Journal of Internal Medicine·M Ingelman-Sundberg
May 27, 2005·The New England Journal of Medicine·Grant R Wilkinson
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·T Andrew ClaytonJeremy K Nicholson
Jan 23, 2009·The Clinical Journal of Pain·Anne N Nafziger, Joseph S Bertino
Aug 14, 2008·Pharmacogenetics and Genomics·Bradley Todd WebbEdwin J C G van den Oord
Apr 3, 2012·Pharmacogenetics and Genomics·Henrik Berg Rasmussen, Christina Mackeprang Dahmcke
May 23, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Alexandra E ShieldsDouglas E Levy
Apr 18, 2008·The Pediatric Infectious Disease Journal·Geneen M Gibson, Geoffrey A Weinberg
Jul 2, 2010·Current Opinion in Pulmonary Medicine·Petal A H M WijnenMarjolein Drent
Dec 12, 2012·Clinical Nurse Specialist CNS·Katherine Chadwell
Jun 14, 2013·Science Translational Medicine·Jeanette J McCarthyGeoffrey S Ginsburg
Nov 28, 2001·Pharmacogenomics·R MarchM Doherty
Sep 12, 2002·Pharmacogenomics·Marina E Chicurel, Dennise D Dalma-Weiszhausz
Sep 1, 2004·Pharmacogenomics·Annalise M MartinSimon Mallal
Feb 28, 2003·Pharmacogenomics·Laszlo T VaszarThomas A Raffin
Jun 19, 2012·Journal of Periodontology·Frederick A CurroFrederick Naftolin
Jan 18, 2007·Molecular Medicine·Jimena V LavanderaAna María Buzaleh
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·J A Johnson
May 19, 2010·Biomarkers in Medicine·Donna L Mendrick, Laura Schnackenberg
Aug 13, 2010·Biomarkers in Medicine·Yuqiu Jiang, Mu Wang
May 20, 2009·Pharmacogenomics·Timothy P YorkEdwin J C G van den Oord
Sep 25, 2010·Clinical Advances in Hematology & Oncology : H&O·Robert Becker, Elizabeth Mansfield
Aug 23, 2012·Croatian Medical Journal·Malak QattanMarija Krstic-Demonacos

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