Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review

Photodiagnosis and Photodynamic Therapy
Yusuke MatobaDaisuke Aoki

Abstract

Several types of photosensitizers such as 5-aminolevulinic acid are progenitors of protoporphyrin IX (PpIX). PpIX accumulates in cancer cells and has photosensitivity. Based on these characteristics, they are used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These methods have recently been applied to gynecologic malignant diseases. Here, we review articles on clinical applications of PDD and PDT for these diseases. A systematic literature search in Pubmed was performed with a combination of keywords to collect the articles. There were eight articles on PDT for uterine cervical diseases, including one study that included patients with cervical cancer. The disease remission rate ranged from 31.6% to 100%. PDD under hysteroscopy had positive effects on endometrial cancer, endometrial hyperplasia and secretory endometrial tissue, and 7 of 11 patients were able to become pregnant after PDT for endometrial cancer. For ovarian cancer, the sensitivity and specificity of clinical PDD were high. There is a need to improve the disease remission rate in uterine cervical diseases, and application of PDT for cervical cancer should be considered. For endometrial cancer, the risks and benefits of PDD that should be compared...Continue Reading

Citations

Jan 23, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hao WuTomonori Yano
Feb 1, 2020·Photochemistry and Photobiology·Michele M Kim, Arash Darafsheh
Feb 23, 2020·Photochemistry and Photobiology·Edward V Maytin, Tayyaba Hasan
Jul 31, 2019·International Journal of Molecular Sciences·Koki KanehiraMasahiro Yao
Apr 25, 2020·Journal of Biomaterials Science. Polymer Edition·Mariana Ribeiro Farah MazzilliAndreza Ribeiro Simioni
Mar 7, 2020·Journal of Orthopaedic Surgery and Research·Shachar KenanAdam S Levin
Oct 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Basma SalamaAkiyoshi Taniguchi
Nov 18, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Tomoyuki HayashiShuichi Kaneko
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Salvador GomezZhiwei Hu
Sep 4, 2021·Advanced Drug Delivery Reviews·Hayoon JeongKun Na

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Abdellah Hamed Khalil AliAkira Tangoku
Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
H SteppWalter Stummer
© 2022 Meta ULC. All rights reserved