PMID: 9533167Apr 9, 1998Paper

Clinical application of time-dependent sensitization to antidepressant therapy

Progress in Neuro-psychopharmacology & Biological Psychiatry
S M Antelman, S Gershon

Abstract

1. A number of animal studies have shown that the actions of numerous drugs can grow or sensitize with the passage of time following even a single treatment, to achieve results equal to or greater than those seen after chronic administration. 2. Our laboratory earlier proposed that this principle might be applied to the treatment of human disorders. It was suggested that the same results might be achieved by giving drugs once every one or two weeks rather than daily, or, even more likely, several-times-daily. 3. Here the authors review the clinical literature relevant to that hypothesis, as it relates to antidepressant therapies. 4. The evidence uniformly supports our earlier thesis that the therapeutic influence of antidepressants would grow with the passage of time, even as their pharmacokinetic actions are declining.

References

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Citations

Apr 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Dziedzicka-WasylewskaM Góralska
Oct 15, 2008·Pharmacology, Biochemistry, and Behavior·Ana G Gutiérrez-García, Carlos M Contreras
Feb 26, 2010·Journal of Neurochemistry·Sylwia Kedracka-KrokMarta Dziedzicka-Wasylewska
Aug 24, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Giovanni A Fava, Emanuela Offidani
May 1, 2001·The International Journal of Neuroscience·I R BellG E Schwartz
Nov 18, 2006·Behavioural Pharmacology·Maciej KuśmiderMarta Dziedzicka-Wasylewska
Aug 25, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neal R SwerdlowGregory A Light
Mar 16, 2001·Bipolar Disorders·I M Salloum, M E Thase

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