Clinical applications of adoptive natural killer cell immunotherapy for cancer: current status and future prospects

Onkologie
Hongfeng Guo, Xifeng Qian

Abstract

Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes involved in the immune defense against viral infections and tumors. NK cells activated with cytokines, such as interleukin-2, have been used since the 1980s as adoptive immunotherapy against cancer. NK cell alloreactivity has been demonstrated to enhance control of acute myeloid leukemia relapse and greatly reduce the risk of graft-versus-host disease in HLA haplotype-mismatched hematopoietic transplantation, and has been explored as a tool for adoptive immunotherapy for cancer patients. Future manipulation to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signaling is being explored.

Citations

Aug 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jian-Dong YuYun-Le Wan
Apr 19, 2019·ESMO Open·Chakor Vora, Sudeep Gupta
Mar 12, 2015·World Journal of Gastroenterology : WJG·Guo-Qing ZhangShun-Chang Jiao
Feb 24, 2017·Frontiers in Immunology·Silke Heidenreich, Nicolaus Kröger
Aug 20, 2019·Immunotherapy·Faezeh GhaemdoustNima Rezaei

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