PMID: 18407075Jan 1, 1992Paper

Clinical applications of GnRH and its analogues

Trends in Endocrinology and Metabolism : TEM
R L Barbieri

Abstract

The chemical characterization of the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH) has stimulated the development of analogues of GnRH with important clinical applications. Chronic administration of the GnRH analogues nafarelin acetate and leuprolide acetate results in an initial stimulation of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which is followed by a profound decrease in the secretion of LH and FSH. The decrease in the secretion of LH and FSH produces a hypogonadal state that is associated with an improvement in many sex-steroid-dependent disease processes. The GnRH analogues are clearly effective in the treatment of prostate cancer, endometriosis, uterine myomas, polycystic ovarian disease, and the premenstrual syndrome.

References

Nov 1, 1990·American Journal of Obstetrics and Gynecology·N Santoro
Feb 25, 1988·The New England Journal of Medicine·R L Barbieri
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·D R MeldrumH L Judd

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Citations

Feb 1, 1995·Cellular and Molecular Neurobiology·S C Sealfon, R P Millar
Jul 1, 1995·Surgical Neurology·S M McReynoldsS F Hussain
Apr 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J S HoE Y Eaker
Oct 1, 1994·Bio/technology·W J De KoningD R Headon
Jul 3, 2013·Nature Reviews. Endocrinology·Robert P Millar, Claire L Newton
Sep 11, 2007·Archives of Histology and Cytology·Katsuyuki KitaharaTsuyoshi Watanabe
Apr 1, 1994·Journal of Endocrinological Investigation·S CostagliolaP Carayon
Jun 15, 2011·International Journal of Pharmaceutics·Marie PribylovaTomas Vanek
Nov 3, 2007·Frontiers in Neuroendocrinology·Robert P MillarZhi-Liang Lu
May 18, 2007·General and Comparative Endocrinology·Ayelet AvitanBerta Levavi-Sivan
Nov 30, 1992·Biochemical and Biophysical Research Communications·S S KakarJ D Neill
Sep 1, 1992·Trends in Endocrinology and Metabolism : TEM·K Gordon, G D Hodgen
Sep 6, 2005·Animal Reproduction Science·Robert P Millar
Sep 9, 2016·Journal of Medicinal Chemistry·Seon-Mi KimJeewoo Lee
Apr 1, 1994·Molecular and Cellular Endocrinology·J S DavidsonR P Millar
Sep 29, 2018·Minerva ginecologica·Claire L NewtonRobert P Millar
Apr 15, 2004·Endocrine Reviews·Robert P MillarStuart R Maudsley
Apr 6, 2002·Archives of Physiology and Biochemistry·C A McArdleJ N Hislop
Jan 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mayuko NagaeHiroko Tsukamura
Jan 8, 2021·ACS Synthetic Biology·Madlen KorneliJörn Piel

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