PMID: 9187942May 1, 1995Paper

Clinical applications of growth hormone for ovarian stimulation

Human Reproduction Update
R Homburg, H Ostergaard

Abstract

The realization of the existence of an intra-ovarian regulating mechanism involving insulin-like growth factor-I (IGF-I), a mediator of growth hormone (GH) action that augments the ovarian response to gonadotrophins, has prompted a number of clinical trials exploring the use of GH as an adjuvant for ovarian stimulation with human menopausal gonadotrophin. A critical review of these studies pinpoints a select group of infertile patients who may benefit from this co-treatment, particularly those who have a surgical, pathological or medically induced dysfunction of GH kinetics. The mechanism of this action, the effective dose needed and the implications regarding the interface of GH, IGF-I and ovarian physiology and pathology are now becoming clearer. A greater understanding of GH action on the ovary may in future benefit patients afflicted by anovulatory infertility and those requiring ovulation induction for in-vitro fertilization.

Citations

Aug 11, 2004·Fertility and Sterility·Antonis VoutetakisIoannis E Messinis
May 1, 1997·British Journal of Obstetrics and Gynaecology·S D KeayJ M Jenkins
Dec 1, 1996·Journal of Endocrinological Investigation·P G ArtiniG D'Ambrogio
Dec 23, 2014·Human Fertility : Journal of the British Fertility Society·Luciano G NardoNeelam Potdar
Nov 20, 2013·Human Fertility : Journal of the British Fertility Society·Ephia Yasmin British Fertility Society
Nov 30, 2012·Human Fertility : Journal of the British Fertility Society·Roy HomburgAnil Gudi
Mar 19, 2002·Human Fertility : Journal of the British Fertility Society·Stephen D Keay
Oct 25, 2016·Clinical Medicine Insights. Endocrinology and Diabetes·Jesús DevesaPablo Devesa
Aug 15, 2013·The Cochrane Database of Systematic Reviews·Ivana RizzutoLesley A Smith
Jun 18, 2019·The Cochrane Database of Systematic Reviews·Ivana RizzutoLesley A Smith
Dec 17, 2018·Reproductive Biology and Endocrinology : RB&E·Roberto MarciDonatella Caserta
Jan 16, 2020·Archives of Endocrinology and Metabolism·Frederick WasinskiJose Donato

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