Nov 1, 1991

Clinical applications of human granulocyte-macrophage colony-stimulating factor

International Journal of Cell Cloning
K M Sakamoto, J C Gasson

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates myeloid cell proliferation and maturation and enhances the function of terminally differentiated effector cells. Phase I and II clinical trials have demonstrated mild to moderate toxicities at doses of less than 30 micrograms/kg/day. These studies suggest a potential role for this growth factor to stimulate myelopoiesis in patients with aplastic anemia, myelodysplastic syndromes, AIDS, chemotherapy-induced myelosuppression, chronic neutropenia, and following bone marrow transplantation. The potential clinical uses of GM-CSF will depend on results of studies designed to optimize its therapeutic efficacy.

Mentioned in this Paper

Aplastic Anemia
Chronic Neutropenia
Colony-Forming Units, Hematopoietic
Neutropenia
IL3 gene
Myelopoiesis
Interleukin-3
Granulocyte-Macrophage Colony-Stimulating Factor
Bone Marrow
Hematopoetic Myelodysplasia

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