Clinical applications of population pharmacokinetic models of antibiotics: Challenges and perspectives

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Femke de VeldeBirgit C P Koch

Abstract

Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is a growing need to optimize the use of old and new antibiotics. Modelling of the pharmacokinetic/pharmacodynamic (PK/PD) characteristics of antibiotics can support the optimization of dosing regimens. Antimicrobial efficacy is determined by susceptibility of the drug to the microorganism and exposure to the drug, which relies on the PK and the dose. Population PK models describe relationships between patients characteristics and drug exposure. This article highlights three clinical applications of these models applied to antibiotics: 1) dosing evaluation of old antibiotics, 2) setting clinical breakpoints and 3) dosing individualization using therapeutic drug monitoring (TDM). For each clinical application, challenges regarding interpretation are discussed. An important challenge is to improve the understanding of the interpretation of modelling results for good implementation of the dosing recommendations, clinical breakpoints and TDM advices. Therefore, also background information on PK/PD principles and approaches to analyse PK/PD data are provided.

Citations

Oct 30, 2019·British Journal of Clinical Pharmacology·Cornelis SmitCatherijne A J Knibbe
Dec 15, 2019·European Journal of Clinical Pharmacology·Shampa DasJianguo Li
Dec 13, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Claude MabilatIsabelle Caniaux
Jun 3, 2020·Antimicrobial Agents and Chemotherapy·Elias TannousSharon Reisfeld
Jul 10, 2020·British Journal of Clinical Pharmacology·Sanne Maartje KloosterboerBirgit C P Koch
Jan 29, 2019·Clinical Pharmacokinetics·Changcheng ShiNengming Lin
Jul 10, 2019·Journal of Clinical Pharmacology·Hechuan WangVijay Ivaturi
Aug 14, 2019·Pediatric Pulmonology·Paulo Caceres GuidoPaula Schaiquevich
Jan 31, 2020·BioMed Research International·Orwa AlbitarSiti Maisharah Sheikh Ghadzi
Aug 7, 2019·Current Drug Metabolism·Ayse Basak Engin, Atilla Engin
Jan 16, 2021·Clinical Pharmacokinetics·Mehdi El HassaniAmélie Marsot
Feb 20, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kannan Sridharan, Amal Al Daylami
Mar 25, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Anne-Grete MärtsonJan-Willem C Alffenaar
Mar 12, 2021·Frontiers in Cellular and Infection Microbiology·Jiachen LiuBimei Jiang
Apr 10, 2021·Expert Review of Clinical Pharmacology·Xiaohui HuangAjing Xu
May 6, 2021·Antibiotics·Alexandre DuongAmélie Marsot
Jun 23, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Aline Vidal Lacerda Gontijo, André V G Cavalieri
Jul 3, 2021·Pharmaceutics·Alicia Rodríguez-GascónArantxa Isla
Jul 27, 2021·Clinical Pharmacology and Therapeutics·Teun van Gelder, Alexander A Vinks
Aug 4, 2021·European Journal of Clinical Pharmacology·Ya-Qian LiQi Pei
Oct 24, 2021·Therapeutic Drug Monitoring·Hannah Yejin KimJan-Willem C Alffenaar

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