Clinical approach to the patient with AKI and sepsis

Seminars in Nephrology
Mélanie GodinRavindra Mehta

Abstract

Sepsis and acute kidney injury (AKI) frequently are combined in critical care patients. They both are associated independently with increased mortality and morbidity. AKI may precede, coincide with, or follow a sepsis diagnosis. Risk factors for sepsis followed by AKI differ from those associated with AKI preceding or coinciding with sepsis, and the pathophysiologic mechanisms may be different. In this article, we review the available clinical, laboratory, and imaging tools available for the recognition of septic AKI. Early identification of high-risk patients and targeted preventive and therapeutic measures are key to reducing the mortality and morbidity of the complex syndrome of septic AKI.

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Apr 12, 2016·The American Journal of Emergency Medicine·Liqiong YaoYunlin Tian
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May 29, 2021·Scientific Reports·Xiaoyuan YangSarah Y Yuan

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