Clinical approaches toward tumor angiogenesis: past, present and future

Current Pharmaceutical Design
Yasuyuki FujitaHiroshi Shimizu

Abstract

Angiogenesis is a complex process which is critical for the growth, invasion, and metastasis of tumors. In the past ten years numerous new agents have been developed as angiogenesis inhibitors. Angiogenesis inhibitors can be classified by their targeted area of the angiogenic process; (1) VEGF and its receptors VEGFR (e.g. Bevacizumab); (2) tyrosine kinases within endothelial cells (Sunitinib); (3) proliferation of endothelial cells (Endostatin); (4) MMPs (Marimastat); (5) intercellular interactions via integrins (Cilengitide) and (6) combinations of the above mechanisms (Thalidomide). Some showed anti-tumor effects with objective responses and stable disease, and some disappeared from clinical use due to unexpected side effects or insufficient efficacies. Further investigations of combined therapies including angiogenesis inhibitors will shed light on the treatment of advanced and metastasized malignancies.

Citations

Mar 13, 2010·Clinical & Experimental Metastasis·Karin StaflinBrunhilde Felding-Habermann
May 6, 2011·Archives of Pharmacal Research·Sheng-Yin ZhaoMei Fan
May 5, 2011·Cancer Biotherapy & Radiopharmaceuticals·Jingping YuSuping Sun
Feb 4, 2010·Pharmacogenetics and Genomics·Michael L MaitlandTeri E Klein
Feb 4, 2010·Digestive Diseases and Sciences·Peng ChengYan Jie Zhang
Aug 15, 2009·Expert Opinion on Investigational Drugs·Pavlos MsaouelMichael Koutsilieris
Sep 24, 2011·Pathology, Research and Practice·Zhengcao LiuXianghong Yang
Jun 2, 2009·Seminars in Cancer Biology·Chiara FrancavillaUgo Cavallaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Arteriosclerosis, Thrombosis, and Vascular Biology
Rita G SilvaLouise E Reynolds
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Daniel J Hicklin, Lee M Ellis
Nature Reviews. Cancer
Christie J AvraamidesJudith A Varner
© 2021 Meta ULC. All rights reserved