Clinical aspects and treatment of immune reactions following penetrating normal-risk keratoplasty

Klinische Monatsblätter für Augenheilkunde
Nhung Xuan NguyenClaus Cursiefen

Abstract

Endothelial graft rejection is one of the most common causes of graft failure following penetrating keratoplasty (PK). The aim of this study was to evaluate the incidence, time course and outcome of treatment of graft rejection after normal-risk PK and to identify possible risk factors for the recurrence of immune reactions and irreversible graft failure. The study included 500 eyes from the prospective Erlanger Normal-risk Keratoplasty Study with a mean follow-up of 42 +/- 18 (median 40) months. Indications for PK were keratoconus in 48 %, Fuchs' dystrophy in 30 %, secondary bullous keratopathy in 11 %, non-vascularized corneal scars in 7 % and stromal dystrophies in 4 %. Standardized complete ophthalmological examinations were performed on a regular basis before, during the acute graft rejection and then regularly in a defined examination raster in an cornea out-patient service. During follow-up 29 eyes (5.6 %) developed an episode of endothelial graft rejection (23 eyes with acute diffuse and 6 eyes with chronic focal rejection type). Episodes of endothelial graft rejection clustered between 11 and 25 months postoperatively (15 from 29, 51.7 %). Most grafts (25 of 29) regained clarity after topical and systemic steroid treat...Continue Reading

Citations

Jan 20, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S MaywegR Sundmacher
May 7, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N J GrossT Reinhard
Feb 15, 2014·The Cochrane Database of Systematic Reviews·Mayank A NanavatyAlex J Shortt
Mar 21, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F BockC Cursiefen
Sep 6, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F BirnbaumT Reinhard
Feb 9, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C Cursiefen, F E Kruse
Sep 10, 2011·Clinical & Experimental Ophthalmology·Nikolaos KopsachilisUlrich Welge Luessen
Oct 4, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Yasmin MolterBerthold Seitz
Jun 7, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C CursiefenL M Heindl

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