PMID: 9658759Jul 11, 1998Paper

Clinical aspects of cryptogenic hepatocellular carcinoma

The Kurume Medical Journal
K Koga

Abstract

Clinical features of hepatocellular carcinoma in 22 patients without serum HBsAg, HBV DNA, anti-HCV antibody and HCV RNA were characterized and possible pathogenic factors for this cryptogenic hepatocellular carcinoma were prospectively assessed. Twenty-two patients were selected from 434 patients with hepatocellular carcinoma (HCC) who were treated at the Second Department of Internal Medicine, Kurume University Hospital between January 1994 and December 1996. Serum samples collected from these patients were all negative for HBsAg, HBV DNA, anti-HCV antibody, and HCV RNA. Patients were evaluated based on past history, present illness, history of habitual alcohol consumption, results of the serological and biochemical laboratory tests at diagnosis of HCC, Anti-HBc antibody, autoantibodies, GBV-C/HGV RNA, and histopathologic findings of non-cancerous portion of the liver were also evaluated. Among 22 patients with non-B non-C HCC, 16 patients (72.7%) had a history of alcoholic liver disease, 6 patients had an infection of schistosomiasis Japonica, and 1 patient had Budd-Chiari syndrome. Nine patients (40.9%) were positive for anti-HBc antibody, but their titers were low in all cases. Among 22 patients, positive for auto antibody...Continue Reading

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