Clinical aspects of Legionnaires' disease
Since the initial description of Legionnaires' disease 2 years ago, a clearer picture of its clinical manifestations has emerged as a result of investigations of further epidemics and studies of laboratory-confirmed sporadic cases. Although individual clinical features are not sufficiently distinctive to distinguish Legionnaires' disease from other types of acute pneumonia, a composite can provide a sufficiently characteristic clinical profile to indicate the likelihood of this diagnosis. Such a profile includes high fever (above 39.4 degrees C); recurrent chills; relative bradycardia; early gastrointestinal symptoms (particularly diarrhea); prominent myalgias; microscopic hematuria; liver function abnormalities; toxic encephalopathy; nonproductive cough; absence of bacterial pathogens on Gram stain and culture of transtracheal aspirate; progression from patchy bronchopneumonia to lobar and multilobar consolidation; and frequently prompt and sometimes dramatic response to treatment with erythromycin.
Opportunistic pneumonia: a clinicopathological study of five cases caused by an unidentified acid-fast bacterium
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-1981
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-1984. Pulmonary infiltrates in a 74-year-old man with multiple lytic defects
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-2000. A 60-year-old farm worker with bilateral pneumonia
Importance of viruses and Legionella pneumophila in respiratory exacerbations of young adults with cystic fibrosis
Legionnaires' disease among pneumonias in Iowa (FY 1972-1978) II. Epidemiologic and clinical features of 30 sporadic cases of L. pneumophila infection
Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia
Legionella pneumophila seen in Gram stains of respiratory secretions and recovered from conventional blood cultures
Legionella pneumophila infection presenting as headache, confusion and dysarthria in a human immunodeficiency virus-1 (HIV-1) positive patient: case report
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 49-1984. A 64-year-old man with rheumatoid arthritis and cavitary pulmonary disease
Cytokine activation of antibacterial activity in human pulmonary macrophages: comparison of recombinant interferon-gamma and granulocyte-macrophage colony-stimulating factor
Brief communication: Legionnaire's disease successfully treated in acute myelocytic leukemia during severe neutropenia
Opportunistic lung infections in renal transplant patients: a comparison of Pittsburgh pneumonia agent and legionnaires' disease
Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.