PMID: 7436934Jul 1, 1980Paper

Clinical assessment of renal function in the dog with a reduction in nephron number

Australian Veterinary Journal
P B EnglishH L Thompson


The viewpoint presented is that, because compensatory functional adjustment of the residual nephrons occurs in chronic renal disease, reduction in nephron number usually exceeds 70% before a diagnosis is made. The case that earlier diagnoses are likely if laboratory medicine values are measured and interpreted with a maximum of efficiency is then made. The laboratory data more commonly used in practice for the clinical assessment of renal function in the dog are presented and some comparisons with findings in man are made. The information originates from clinical and experimental observations of the authors, as well as from a literature review. The laboratory data presented and discussed includes glomerular filtration rate and the clearance of nitrogenous waste (urea and creatinine), plasma protein concentration, plasma osmolality, renal concentrating capacity, and urinary constituents, particularly its protein concentration and sediment (centrifuge deposit). All parameters recommended for the clinical assessment of chronic renal failure are considered qualitatively, and some are also dealt with quantitatively.


Feb 1, 1977·The Journal of Small Animal Practice·P Bown
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Sep 1, 1990·New Zealand Veterinary Journal·B R JonesJ Cayzer
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Mar 17, 2007·Renal Failure·Viroj Wiwanitkit, Prapawadee Ekawong

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