Clinical assessment of target-controlled infusion of propofol during monitored anesthesia care

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Andrea CasatiGiorgio Torri

Abstract

To determine the plasma concentrations of propofol required to achieve different levels of sedation during monitored anesthesia care. Sixty ASA I-II, 18-65 yr-old patients, received a target-controlled continuous iv infusion of propofol. The target plasma concentration of propofol (Cpt) was initially set at 0.4 microg x ml(-1). Two minutes after calculated equilibrium between plasma and effect-site concentrations, the Cpt of propofol was increased by 0.2 microg x ml(-1) steps until the patient showed no reaction to squeezing the trapezius. The level of sedation was assessed immediately before each increase in propofol Cpt using the Observer's Assessment of Alertness/Sedation (OAA/S) scale. The Cpt of propofol required to induce lethargic response to name was 1.3 microg x ml(-1) (5 degrees and 95 degrees percentiles: 1.0 - 1.8 microg x ml(-1)), to obtain response after loud and repeated calling name was 1.7 microg x ml(-1) (1.2 - 2.2 microg x ml(-1)), to obtain response after prodding or shaking was 2.0 microg x ml(-1) (1.6 - 2.6 microg x ml(-1)), to obtain response after squeezing the trapezius was 2.4 microg x ml(-1) (1.8 - 3.0 microg x ml(-1)). Patients showed no response after squeezing the trapezius at 2.8 microg x ml(-1) (...Continue Reading

References

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Citations

Jan 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Satoki InoueToshisuke Sakaki
Aug 28, 2004·Gastrointestinal Endoscopy·Lorella FantiPier Alberto Testoni
Jun 6, 2003·The Veterinary Journal·L BergamascoA Jaggy
Jan 9, 2010·Therapeutics and Clinical Risk Management·Eric A HarrisKeith A Candiotti
Nov 15, 2006·Journal of Clinical Monitoring and Computing·Leslie C Jameson, Tod B Sloan
Jan 3, 2012·Journal of Clinical Monitoring and Computing·Bo LiuGavin Troughton
Jun 15, 2011·Journal of Clinical Anesthesia·Crina L BurlacuAlan J McShane
Nov 9, 2010·Journal of Clinical Anesthesia·Jung-Hee RyuSang-Hwan Do
Jan 1, 2016·Journal of Critical Care·Emmanuel LafontChristophe Faisy
May 21, 2003·The Journal of Obstetrics and Gynaecology Research·Ketchada UerpairojkitWanna Somboonviboon
Jun 8, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Chizuko YokoeHitoshi Niwa
Apr 6, 2005·Journal of Clinical Anesthesia·Andrea Casati, Marta Putzu
Dec 15, 2017·Critical Care Medicine·Adéla KrajčováFrantišek Duška
Aug 3, 2016·Korean journal of anesthesiology·Hye-Min Sohn, Jung-Hee Ryu
Jun 7, 2013·Korean journal of anesthesiology·Tae-Yop Kim
Oct 5, 2006·Current Opinion in Anaesthesiology·M Chollet-Rivier, R L Chioléro
Apr 10, 2002·Anaesthesia and Intensive Care·A B P DonaldsonA Roux

Related Concepts

Propofol Rovi
Therapeutic Drug Monitoring
Anesthetics, Intravenous

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