PMID: 11927298Apr 3, 2002Paper

Clinical association with urinary glycosaminoglycans and urolithiasis

Urology
Erdal ErturkSusan R Schoen

Abstract

To determine the clinical association between urinary glycosaminoglycan (GAG) concentration and kidney stone disease. Thirty-five patients (14 women and 21 men) with a history of stone disease and 37 controls (13 women and 24 men) were evaluated for urinary GAG concentration. By using a new dye-binding assay, the total GAG concentration in the urine was measured and corrected to urinary creatinine levels (micrograms of GAG per milligram creatinine). The mean urinary GAG concentration in those with stones was significantly lower (31.5 +/- 2.6 microg GAG/mg creatinine) than in the controls (43.8 +/- 3.8 microg GAG/mg creatinine, P = 0.01). Male patients with stones also had a significantly lower mean GAG concentration (26.1 +/- 1.8) than did the female patients (39.6 +/- 5.3, P = 0.009). The mean GAG concentration between ureteral (n = 13) versus renal (n = 22), single (n = 19) versus multiple (n = 16), family history (n = 11) versus no family history (n = 24), large (n = 13) versus small (n = 20), and the presence (n = 22) versus absence (n = 13) of residual stones did not show any significant differences. However, patients with recurrent stone formation (n = 21) had significantly lower mean GAG levels (26.4 +/- 1.6) compared wi...Continue Reading

References

Jan 29, 1976·The New England Journal of Medicine·W G RobertsonB E Nordin
Jan 1, 1992·Nephron·A NesseJ R Zanchetta
Nov 16, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·L P Thuy, W L Nyhan
Dec 1, 1989·Kidney International·Y M MichelacciN Schor
Dec 1, 1987·British Journal of Urology·R L RyallV R Marshall
May 1, 1969·Journal of Clinical Pathology·C A Pennock
Jul 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·L BorghiA Novarini
Jan 1, 1994·Nephron·F GrasesJ G March
Mar 9, 1996·Molecular and Cellular Biochemistry·D SenthilP Varalakshmi
Jun 2, 1998·International Urology and Nephrology·P WinterA Hesse
May 18, 1999·Archives of Disease in Childhood·T AkçayY Dínçer

❮ Previous
Next ❯

Citations

Mar 22, 2007·Seminars in Dialysis·Georg SchlieperMarkus Ketteler
Oct 24, 2013·BioMed Research International·Kanu Priya AggarwalChanderdeep Tandon
Oct 30, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Agnieszka Torzewska, Antoni Różalski
Mar 8, 2019·PloS One·Thasinas DissayabutraPiyaratana Tosukhowong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.