Clinical associations of anosognosia in mild cognitive impairment and Alzheimer's disease

International Journal of Geriatric Psychiatry
E MakS Hameed

Abstract

While loss of insight of cognitive deficits is a common phenomenon in patients with Alzheimer's disease (AD), there is a lack of consensus regarding the presence of impaired insight among patients with mild cognitive impairment (MCI). We aim to investigate the clinical, cognitive, and behavioral associations of anosognosia in AD and MCI subjects. A consecutive series of 87 subjects (30 healthy older patients, 21 MCI, and 36 AD) each accompanied by a caregiver, underwent clinical assessment including the evaluation of insight using the Anosognosia Questionnaire for Dementia (AQD). We also separately assessed Intellectual Function (AQD-IF) and Behavior domains of the AQD scale. Regression models were subsequently used to investigate associations of AQD scores with cognitive and other neuropsychiatric symptoms, including depression and apathy. Both AD and MCI groups demonstrated significant anosognosia compared with the healthy control group. In the AD group, 55.6% had "Mild Anosognosia," and 27.8% had "Severe Anosognosia." In the MCI group, 42.9% showed "Mild Anosognosia," and 9.5% had "Severe Anosognosia." Greater levels of AQD-Total and AQD-IF were associated with lower Mini-mental state examination and higher apathy scores in ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Dec 1, 1980·The Gerontologist·S H ZaritJ Bach-Peterson
Jan 1, 1995·The Journal of Neuropsychiatry and Clinical Neurosciences·R MigliorelliS E Starkstein
Nov 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR Leiguarda
Jul 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·S E StarksteinR Leiguarda
Apr 10, 2002·Journal of the International Neuropsychological Society : JINS·Susan McPhersonCarla Back-Madruga
Mar 22, 2003·Schizophrenia Research·Alisa R MintzDavid M Romney
Jan 24, 2004·Dementia and Geriatric Cognitive Disorders·Asmus VogelGunhild Waldemar
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Apr 2, 2005·Dementia and Geriatric Cognitive Disorders·E KalbeK Herholz
Mar 22, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR G Robinson
Apr 28, 2007·International Review of Psychiatry·Christoph Lauber, Wulf Rössler
Jun 10, 2009·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Paul M JenkinsonSimon J Ellis
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Maria Donata OrfeiGianfranco Spalletta
Nov 3, 2010·The Journal of Neuropsychiatry and Clinical Neurosciences·Sergio E StarksteinGustavo Petracca
Feb 22, 2012·Journal of Alzheimer's Disease : JAD·Gianfranco SpallettaMaria Donata Orfei
May 5, 2012·International Journal of Geriatric Psychiatry·Oriol Turró-GarrigaSecundino López-Pousa
Sep 22, 2012·Journal of the International Neuropsychological Society : JINS·Martina AmanzioGiuliano Geminiani
Apr 20, 2013·Archives of Gerontology and Geriatrics·Sandra VerhülsdonkTillmann Supprian
Dec 18, 2013·Journal of the International Neuropsychological Society : JINS·Daniel C Mograbi, Robin G Morris

❮ Previous
Next ❯

Citations

Dec 9, 2015·International Journal of Geriatric Psychiatry·Mary KelleherJames E Galvin
Apr 20, 2017·Journal of Geriatric Psychiatry and Neurology·Bora YoonDong-Won Yang
Nov 23, 2017·Alzheimer Disease and Associated Disorders·Isabel B LacerdaMarcia C N Dourado
Aug 26, 2017·American Journal of Alzheimer's Disease and Other Dementias·Ilaria CovaSimone Pomati
Nov 8, 2016·Alzheimer Disease and Associated Disorders·Sandra VerhülsdonkElke Kalbe
Sep 7, 2020·International Journal of Geriatric Psychiatry·Simon CloutierSylvie Belleville
Sep 16, 2017·Gerontology & Geriatric Medicine·Curtis TatsuokaMartha Sajatovic
Aug 14, 2019·Journal of Geriatric Psychiatry and Neurology·Hannah E BrunetJustin B Miller
Jan 30, 2020·Scientific Reports·Alexis MitelpunktYoav Benjamini
Jul 25, 2017·Dementia and Geriatric Cognitive Disorders·Janine SteinUNKNOWN AgeCoDe and AgeQualiDe Study Group
Feb 7, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kenji TagaiKazuhiko Nakayama
Jun 20, 2019·Journal of Geriatric Psychiatry and Neurology·P WibawaS E Starkstein
Aug 21, 2021·Frontiers in Aging Neuroscience·Federica CacciamaniStéphane Epelbaum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.