Clinical Benefit of Hepatic Arterial Infusion Concurrent Chemoradiotherapy in Locally Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Hong In YoonJinsil Seong

Abstract

The aim of this study was to evaluate whether hepatic arterial infusion concurrent chemoradiotherapy (CCRT) could improve overall survival (OS) in patients with locally advanced hepatocellular carcinoma (LAHCC). Two databases were reviewed from Yonsei Cancer Center (YCC) and Korean Liver Cancer Study Group (KLCSG) nationwide multi-center hepatocellular carcinoma (HCC) cohort. The CCRT group included 106 patients, with stage III-IV, Child-Pugh classification A, Eastern Cooperative Oncology Group performance status 0 or 1, who underwent definitive CCRT as the initial treatment at YCC. We used propensity score matching to adjust for seven clinical factors, including age, tumor size, TNM stage by the Liver Cancer Study Group of Japan, T stage, Barcelona Clinic Liver Cancer (BCLC) staging system, etiology of HCC, and portal vein invasion, which all differed significantly in the two databases. From the KLCSG cohort enrolled at 32 institutions, 106 patients for the non-CCRT group were defined. After propensity score matching, all patient characteristics were balanced between the two groups. The CCRT group had better OS (median, 11.4) than the non-CCRT group (6.6 months, p=0.02). In multivariate analyses for all patients, CCRT (hazard ...Continue Reading

References

Dec 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G B StillwagonE K Fishman
Feb 24, 2001·Clinical Oncology : a Journal of the Royal College of Radiologists·UNKNOWN Regional Thyroid Cancer Group
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edgar Ben-JosefTheodore S Lawrence
Nov 4, 2006·The Lancet Oncology·Anne FleissigLesley Fallowfield
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Sep 18, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Jinsil SeongChul Joo Han
Nov 17, 2009·Surgical Oncology Clinics of North America·Adam C Yopp, William R Jarnagin
Apr 14, 2010·Journal of the National Cancer Institute. Monographs·Mary L FennellAndrew Salner
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
May 31, 2011·International Journal of Radiation Oncology, Biology, Physics·Sang Min YoonDong Jin Suh
Oct 14, 2011·Future Oncology·Mersiha HadziahmetovicArnab Chakravarti
Dec 18, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Kyung Hwan KimJinsil Seong

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BETA
surgical resection

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Carcinoma, Hepatocellular

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