Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

Nature
B. WilliamsonEmmie de Wit

Abstract

Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While many investigational, approved, and repurposed drugs have been suggested as potential treatments, preclinical data from animal models can guide the search for effective treatments by ruling out those that lack efficacy in vivo. Remdesivir (GS-5734) is a nucleotide analogue prodrug with broad antiviral activity1,2 that is currently being investigated in COVID-19 clinical trials and recently received Emergency Use Authorization from the US Food and Drug Administration3,4. In animal models, remdesivir was effective against infection with Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV)2,5,6. In vitro, remdesivir inhibited replication of SARS-CoV-27,8. Here we investigate the efficacy of remdesivir in a rhesus macaque model of SARS-CoV-2 infection9. Unlike vehicle-treated animals, macaques treated with remdesivir did not show signs of respiratory disease; they also showed reduced pulmonary infiltrates on radiographs and reduced virus titres in bronchoalveolar lavages twelve hours after the first dose. Virus shedding from the upper respiratory tract was not reduced by remdesi...Continue Reading

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Citations

Jun 20, 2020·Journal of Medical Virology·Lubna Pinky, Hana M Dobrovolny
Jul 4, 2020·MBio·Liise-Anne Pirofski, Arturo Casadevall
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Methods Mentioned

BETA
lavage
PCR
bronchoalveolar lavages

Software Mentioned

bcftools
Bowtie2
cutadapt
GATK HaplotypeCaller
- Toolkit
GraphPad Prism
FASTX

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