Clinical benefit of sequential three-step empirical therapy in the management of chronic cough

Respirology : Official Journal of the Asian Pacific Society of Respirology
Li YuCuiqin Shi

Abstract

A prospective study was conducted to investigate the efficacy of empirical therapy in the management of chronic cough. A three-step empirical therapy protocol was used to treat patients who had a chronic cough and a normal CXR and normal lung function testing. In step one antihistamine decongestants plus bronchodilators were taken, corticosteroids in the second step, and a combination of a proton pump inhibitor and a prokinetic agent in the third step. Cough symptom scores were recorded before and after each step in the protocol. There were 102 patients recruited; mean age 49 +/- 16 years and with a history of cough of between 2 and 120 months at presentation. The cough resolved in 67.6% (n = 69) of the patients after the first-step therapy; in a further 12.7% (13) after the second-step therapy, and in another 7.8% (8) after the third-step of the treatment protocol. In three patients cough improved after the first-step of therapy but only achieved complete resolution when this treatment was combined with the third-step therapy. Overall, the three-step empirical therapy was successful in 88.2% (n = 90) of the patients. Cough symptom scores decreased from 3.30 +/- 0.75 to 0.30 +/- 0.97 (P < 0.001). The mean duration of treatment ...Continue Reading

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Citations

Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Weili WeiZhongmin Qiu
Jul 26, 2013·World Journal of Gastroenterology : WJG·Xiang-Huai XuZhong-Min Qiu
Oct 22, 2011·Revue de pneumologie clinique·S Chomette-BallereauJ-M Vergnon
Jan 27, 2015·The Clinical Respiratory Journal·Hai-Yan DengKe-Fang Lai
Sep 11, 2016·Chest·Peter J KahrilasUNKNOWN CHEST Expert Cough Panel
Jun 10, 2017·Therapeutic Advances in Respiratory Disease·Li YuZhongmin Qiu
Apr 17, 2018·Expert Opinion on Pharmacotherapy·Nicole M RyanSurinder S Birring
Jul 22, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Kefang LaiNanshan Zhong
Jan 26, 2021·Therapeutic Advances in Chronic Disease·Mengru ZhangZhongmin Qiu

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