Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.

ESMO Open
Y HibinoS Kondo

Abstract

Precision and matched cancer medicine has the potential to complement the existing biomarker approaches in cancer treatment. However, despite their promising potential, certain negative results have highlighted their limitations in molecular biology-driven treatment strategies. This study aimed to evaluate the clinical benefits of precision therapies. Three reviewers independently identified and assessed precision and matched cancer treatment studies published between January 2015 and December 2020. Clinical benefits of the treatments included in our cohort were assessed using two established frameworks; the European Society of Medical Oncology-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS) and the American Society of Clinical Oncology Value Framework. Of the 290 eligible studies, 130 were for lung cancer, 51 for solid tumors, 24 for melanoma, and 24 for breast cancer. The common targets were: epidermal growth factor receptor (N = 66), serine/threonine-protein kinase B-Raf (N = 40), anaplastic lymphoma kinase (ALK) (N = 34), breast cancer protein (N = 26), phosphatidylinositol-3 kinase/protein kinase B/phosphatase and tensin homolog (PI3K/AKT/PTEN) pathway (N = 19), receptor tyrosine-protein kinase erbB-2 (HER2) (N...Continue Reading

References

May 14, 2008·Current Cancer Drug Targets·Amancio CarneroJuan F M Leal
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Oct 2, 2012·The New England Journal of Medicine·Keith T FlahertyJeffrey Weber
Dec 4, 2014·The New England Journal of Medicine·Benjamin J SolomonUNKNOWN PROFILE 1014 Investigators
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amanda J Redig, Pasi A Jänne
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria SchwaederleRazelle Kurzrock
Sep 18, 2015·Journal of the National Cancer Institute·Denis L JardimRazelle Kurzrock
Jun 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lowell E SchnipperRichard L Schilsky
Feb 12, 2017·Cell·Arthur W LambertRobert A Weinberg
Jul 6, 2017·The New England Journal of Medicine·Janet Woodcock, Lisa M LaVange
Apr 17, 2018·The New England Journal of Medicine·Matthew D HellmannLuis Paz-Ares
May 16, 2019·The New England Journal of Medicine·Fabrice AndréUNKNOWN SOLAR-1 Study Group
Jan 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C Del PaggioC M Booth
May 30, 2020·The New England Journal of Medicine·Paul K PaikXiuning Le
Sep 3, 2020·The New England Journal of Medicine·Jürgen WolfUNKNOWN GEOMETRY mono-1 Investigators
Sep 22, 2020·The New England Journal of Medicine·David S HongBob T Li

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