Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy

Spinal Cord
N D JefferyR J M Franklin

Abstract

Review. To highlight the value of investigating the effects of putative therapeutic interventions in clinical spinal cord injury (SCI) in domestic dogs. England, UK. Many experimental interventions in laboratory rodents have been shown to ameliorate the functional deficits caused by SCI; the challenge now is to determine whether they can be translated into useful clinical techniques. Important differences between clinical SCI in human patients and that in laboratory rodents are in the size of the spinal cord and heterogeneity of injury severity. A further key issue is whether the statistical difference in outcome in the laboratory will translate into a useful difference in clinical outcome. Here, we stress the value of investigating the effects of putative therapies in clinical SCI in domestic dogs. The causes of injury, ability to categorise the severity and methods available to measure outcome are very similar between canine and human patients. Furthermore, postmortem tissue more rapidly becomes available from dogs because of their short lifespan than from human patients. The role that investigation of canine SCI might play is illustrated by our preliminary trials on intraspinal transplantation of olfactory glial cells for se...Continue Reading

References

May 1, 1990·Journal of Pharmacological Methods·T Hashimoto, N Fukuda
Jun 1, 1989·Journal of the Neurological Sciences·S G Waxman
Apr 1, 1989·Journal of Neuroscience Methods·C W VanderzantL G D'Alecy
Jun 1, 1972·Journal of Neurology, Neurosurgery, and Psychiatry·I R Griffiths
Oct 1, 1993·Journal of Neurosurgery·O al-MeftyW F Russell
Feb 1, 1997·Journal of Neuroscience Methods·M G Fehlings, R Nashmi
Nov 20, 1998·Archives of Physical Medicine and Rehabilitation·N Westgren, R Levi
May 18, 1999·Archives of Physical Medicine and Rehabilitation·J W LittleR M Harris
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Sep 29, 1999·The Veterinary Record·N D Jeffery, W F Blakemore
Oct 12, 1999·The Journal of Small Animal Practice·H W Scott, W M McKee
Dec 3, 1999·The European Journal of Neuroscience·E J BradburyS B McMahon
Feb 19, 2000·The Veterinary Clinics of North America. Small Animal Practice·I F Lane
Feb 19, 2000·The Veterinary Clinics of North America. Small Animal Practice·J R Coates
Apr 3, 2001·Expert Opinion on Investigational Drugs·A I Maas
May 2, 2001·Nature Reviews. Neuroscience·G Raisman
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·M B Bunge
Oct 11, 2001·American Journal of Veterinary Research·N J OlbyB W Keene
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
May 31, 2002·Nature·Tadzia GrandPréStephen M Strittmatter
Jun 4, 2002·Journal of Neurotrauma·Raj K NarayanLorraine Yurkewicz
Aug 17, 2002·Trends in Neurosciences·Volker Dietz
Nov 21, 2002·Progress in Brain Research·Wise Young
Nov 21, 2002·Progress in Brain Research·Barbara S BregmanFaheem Sandhu
Nov 21, 2002·Progress in Brain Research·Martin E Schwab
Feb 19, 2003·Brain Research. Brain Research Reviews·Trevor DrewWitold Widajewicz
Apr 5, 2003·Journal of the American Veterinary Medical Association·Natasha OlbyNick Sharp
Jun 14, 2003·Brain : a Journal of Neurology·Jennifer E A WellsV Wee Yong
Jul 10, 2003·Lancet Neurology·Kathryn Senior
Jul 29, 2003·Spinal Cord·G ScivolettoM Molinari
Sep 5, 2003·Emergency Medicine Journal : EMJ·S R JonesM Harrison

❮ Previous
Next ❯

Citations

Mar 29, 2011·Journal of Neurotrauma·Jonathan M LevineLinda J Noble-Haeusslein
May 24, 2011·Journal of Neurotrauma·Theda Marie Anne BoekhoffVeronika Maria Stein
Nov 27, 2008·BMC Veterinary Research·Lindsay HamiltonNicholas D Jeffery
Jul 11, 2012·Stem Cell Research & Therapy·Eleanor M DonnellyNicholas M Boulis
May 3, 2014·PloS One·Jonathan M LevineLinda J Noble-Haeusslein
Mar 7, 2014·BMC Veterinary Research·Natasha J OlbyAudrey Muguet-Chanoit
Dec 3, 2014·The Veterinary Clinics of North America. Small Animal Practice·Nicolas Granger, Darren Carwardine
Jul 16, 2011·Journal of Neuropathology and Experimental Neurology·Ingo SpitzbarthAndreas Beineke
May 1, 2012·Veterinary Immunology and Immunopathology·I SpitzbarthA Beineke
Jan 26, 2013·Journal of Magnetic Resonance Imaging : JMRI·John F GriffinJonathan M Levine
Aug 24, 2010·Journal of Neuroimmunology·Eva-Maria EnsingerVeronika M Stein
Aug 15, 2015·Stem Cells Translational Medicine·Barbara G McMahillBeverly K Sturges
Feb 28, 2018·Journal of Neuroscience Research·Changbin LiuZhentao Zuo
Nov 23, 2017·PloS One·Neringa AlisauskaiteAndrea Tipold
May 1, 2018·Journal of Molecular Neuroscience : MN·Nicole JungwirthFlorian Hansmann
Jul 31, 2013·Journal of Biomechanical Engineering·Claire F JonesPeter A Cripton
Mar 3, 2019·International Journal of Molecular Sciences·Sarah SchwarzAnnika Lehmbecker
Jul 31, 2019·Stem Cells and Development·Xiaoqiang CongJiesi Luo
Jan 10, 2020·Journal of Neurotrauma·Natasha OlbyUNKNOWN CANSORT SCI Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cambridge Stem Cell Institute - Researcher Network

Cambridge Stem Cell Institute's mission is to transform human health through a deep understanding of stem cell biology. Follow this feed to stay up to date on research published in this group.