PMID: 7539828Feb 1, 1995Paper

Clinical characteristics and antibody profiles of chronic hepatitis C patients: relation to hepatitis C virus genotypes

Journal of Medical Virology
N YukiT Kamada

Abstract

Genotyping of 179 consecutive Japanese chronic hepatitis C patients was carried out based on the variation in the hepatitis C virus (HCV) core gene. The results were correlated with clinical features and antibody responses toward specific HCV proteins deduced from the nucleotide sequence of genotype I/1a. Genotypes II/1b, III/2a, and IV/2b were identified in 138 (77%), 24 (13%), and 12 (7%) patients, respectively. Five patients had double infections. Genotype dependence was observed only for antibody response toward the NS4 (5-1-1) protein, which was infrequent in genotype III/2a patients (33%) compared with genotype II/1b (81%; P < 0.01) and genotype IV/2b (75%; P < 0.05). Following interferon-alpha therapy, sustained amniotransferase normalisation was achieved by 89% (eight of nine) patients without antibody to the 5-1-1 protein and 33% (17 of 51) with it (P < 0.01). These findings indicate that absence of antibody response to the 5-1-1 protein is frequent in genotype III/2a HCV carriers and may serve to predict responses to interferon therapy.

References

Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J G McHutchisonR DiNello
Feb 1, 1992·Gastroenterology·H HagiwaraT Kamada
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K YoshiokaT Morishima
Oct 1, 1992·Digestive Diseases and Sciences·N YukiH Okayama
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H HagiwaraT Kamada
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Q L ChooP J Barr
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N KatoK Shimotohno
May 18, 1989·Nature·S Kwok, R Higuchi
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TanakaM Kohara
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N YukiT Kamada
May 1, 1994·Digestive Diseases and Sciences·E MitaT Kamada
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NaitoT Kamada
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SimmondsD S Chen
Mar 1, 1993·Journal of Gastroenterology and Hepatology·K ChayamaS Koyama
Mar 1, 1993·Journal of Hepatology·N TakadaT Date

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Citations

Nov 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F GarcíaM C Maroto
Jan 6, 2000·Journal of Hepatology·M U Mondelli, E Silini
Jan 1, 1995·Journal of Viral Hepatitis·Y H AbaciogluP Simmonds
Jul 10, 2004·Journal of Clinical Microbiology·Cécile HenquellHélène Peigue-Lafeuille
Oct 6, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G LodiS R Porter
Jun 11, 2009·Biomedit︠s︡inskai︠a︡ khimii︠a︡·L I NikolaevaD K L'vov

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